Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma

Wei Fan Chiang, Shyun Yeu Liu, Lai Ya Fang, Ching Nan Lin, Ming Heng Wu, Yen Chia Chen, Yuh Ling Chen, Ying Tai Jin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Metastasis is a final and eventually fatal step in the progression of oral squamous cell carcinoma (OSCC) and typically accompanies a large primary tumor. Metastasis may also present from a small primary tumor and progress rapidly; therefore, early diagnosis is important for patients with small primary tumors. Galectin-1 is one significantly upregulated tumor-associated protein in many neoplasms. To determine the clinical significance of galectin-1, we analyzed its expression in clinical samples by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction assay. Galectin-1 protein was significantly overexpressed in the tumor-associated stroma as well as the invasion front during early oral carcinogenesis (P <0.05). During the metastatic stage, the only significant immunoreactivity was at the tumor invasion front (P <0.05). Although galectin-1 mRNA was not significantly upregulated in the whole cancerous tissue, it was upregulated in stromal parts during early-stage OSCC and in epithelial parts at the metastatic stage. Survival analysis and a Cox's proportional hazards model showed that synchronous upregulation of galectin-1 protein and mRNA was correlated with worse disease-free survival in early-stage OSCC (P = 0.024 and P = 0.047, respectively). Our findings suggest that galectin-1 upregulation at the tumor invasion front might be a predictor of early metastasis in oral carcinogenesis.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalOral Oncology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Fingerprint

Oral Stage
Galectin 1
Squamous Cell Carcinoma
Neoplasms
Neoplasm Metastasis
Carcinogenesis
Up-Regulation
Messenger RNA
Proteins
Survival Analysis
Proportional Hazards Models
Reverse Transcription
Disease-Free Survival
Early Diagnosis
Immunohistochemistry

Keywords

  • Galectin-1
  • Invasion front
  • Oral squamous cell carcinoma
  • Tumor microenvironment
  • Tumor-associated stroma

ASJC Scopus subject areas

  • Oncology

Cite this

Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. / Chiang, Wei Fan; Liu, Shyun Yeu; Fang, Lai Ya; Lin, Ching Nan; Wu, Ming Heng; Chen, Yen Chia; Chen, Yuh Ling; Jin, Ying Tai.

In: Oral Oncology, Vol. 44, No. 4, 04.2008, p. 325-334.

Research output: Contribution to journalArticle

Chiang, Wei Fan ; Liu, Shyun Yeu ; Fang, Lai Ya ; Lin, Ching Nan ; Wu, Ming Heng ; Chen, Yen Chia ; Chen, Yuh Ling ; Jin, Ying Tai. / Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. In: Oral Oncology. 2008 ; Vol. 44, No. 4. pp. 325-334.
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