Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma

Sung Wei Lee, Ching Yih Lin, Yu Feng Tian, Ding Ping Sun, Li Ching Lin, Li Tzong Chen, Chung Hsi Hsing, Chiang Ting Huang, Han Ping Hsu, Hsuan Ying Huang, Li Ching Wu, Chien Feng Li, Yow Ling Shiue

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p = 0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p 

Original languageEnglish
Pages (from-to)206-214
Number of pages9
JournalAPMIS
Volume122
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Fingerprint

Protein Kinases
Data Mining
Survival
Public Sector
Protein Subunits
Nasopharyngeal carcinoma
Multivariate Analysis
Guidelines
Neoplasm Metastasis
Biopsy
Neoplasms

Keywords

  • CDC28 protein kinase regulatory subunit 1B
  • CKS1B
  • Nasopharyngeal carcinoma
  • Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology and Allergy

Cite this

Lee, S. W., Lin, C. Y., Tian, Y. F., Sun, D. P., Lin, L. C., Chen, L. T., ... Shiue, Y. L. (2014). Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. APMIS, 122(3), 206-214. https://doi.org/10.1111/apm.12136

Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. / Lee, Sung Wei; Lin, Ching Yih; Tian, Yu Feng; Sun, Ding Ping; Lin, Li Ching; Chen, Li Tzong; Hsing, Chung Hsi; Huang, Chiang Ting; Hsu, Han Ping; Huang, Hsuan Ying; Wu, Li Ching; Li, Chien Feng; Shiue, Yow Ling.

In: APMIS, Vol. 122, No. 3, 03.2014, p. 206-214.

Research output: Contribution to journalArticle

Lee, SW, Lin, CY, Tian, YF, Sun, DP, Lin, LC, Chen, LT, Hsing, CH, Huang, CT, Hsu, HP, Huang, HY, Wu, LC, Li, CF & Shiue, YL 2014, 'Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma', APMIS, vol. 122, no. 3, pp. 206-214. https://doi.org/10.1111/apm.12136
Lee, Sung Wei ; Lin, Ching Yih ; Tian, Yu Feng ; Sun, Ding Ping ; Lin, Li Ching ; Chen, Li Tzong ; Hsing, Chung Hsi ; Huang, Chiang Ting ; Hsu, Han Ping ; Huang, Hsuan Ying ; Wu, Li Ching ; Li, Chien Feng ; Shiue, Yow Ling. / Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. In: APMIS. 2014 ; Vol. 122, No. 3. pp. 206-214.
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