Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma

Sung Wei Lee, Ching Yih Lin, Yu Feng Tian, Ding Ping Sun, Li Ching Lin, Li Tzong Chen, Chung Hsi Hsing, Chiang Ting Huang, Han Ping Hsu, Hsuan Ying Huang, Li Ching Wu, Chien Feng Li, Yow Ling Shiue

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6 Citations (Scopus)

Abstract

Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p = 0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p 

Original languageEnglish
Pages (from-to)206-214
Number of pages9
JournalAPMIS
Volume122
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Keywords

  • CDC28 protein kinase regulatory subunit 1B
  • CKS1B
  • Nasopharyngeal carcinoma
  • Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology and Allergy

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  • Cite this

    Lee, S. W., Lin, C. Y., Tian, Y. F., Sun, D. P., Lin, L. C., Chen, L. T., Hsing, C. H., Huang, C. T., Hsu, H. P., Huang, H. Y., Wu, L. C., Li, C. F., & Shiue, Y. L. (2014). Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. APMIS, 122(3), 206-214. https://doi.org/10.1111/apm.12136