Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia

Georg Northoff, Javier Gomez-Pilar

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Schizophrenia is a complex psychiatric disorder exhibiting alterations in spontaneous and task-related cerebral activity whose relation (termed "state dependence") remains unclear. For unraveling their relationship, we review recent electroencephalographic (and a few functional magnetic resonance imaging) studies in schizophrenia that assess and compare both rest/prestimulus and task states, ie, rest/prestimulus-task modulation. Results report reduced neural differentiation of task-related activity from rest/prestimulus activity across different regions, neural measures, cognitive domains, and imaging modalities. Together, the findings show reduced rest/prestimulus-task modulation, which is mediated by abnormal temporospatial dynamics of the spontaneous activity. Abnormal temporospatial dynamics, in turn, may lead to abnormal prediction, ie, predictive coding, which mediates cognitive changes and psychopathological symptoms, including confusion of internally and externally oriented cognition. In conclusion, reduced rest/prestimulus-task modulation in schizophrenia provides novel insight into the neuronal mechanisms that connect task-related changes to cognitive abnormalities and psychopathological symptoms.

Original languageEnglish
Pages (from-to)751-765
Number of pages15
JournalSchizophrenia bulletin
Volume47
Issue number3
DOIs
Publication statusPublished - Apr 29 2021
Externally publishedYes

Keywords

  • common currency
  • predictive coding
  • rest–task modulation
  • state dependence
  • temporospatial dynamics

ASJC Scopus subject areas

  • Psychiatry and Mental health

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