Overall and event-free survivals for acute lymphoblastic leukemia in children at a single institution in Taiwan

Hsi Che Liu, Shu Huey Chen, Kou Hwa Chang, Le Chiao Chiang, Chin Yueh Liu, Huei Lan Chang, Li Li Tsai, Der Cherng Liang

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7 Citations (Scopus)

Abstract

The results of treatment for childhood acute lymphoblastic leukemia (ALL) have improved dramatically over the past three decades. The authors present the long-term outcome of patients (n = 151) with ALL enrolled in 4 consecutive clinical trials conducted from 1982 to 1993 at Mackay Memorial Hospital. During this period, the backbone of the treatment remained relatively unchanged, including a 3- to 4-drug remission induction, central nervous system (CNS)-directed therapy, and cyclic pulses of vincristine and dexamethasone during maintenance therapy. More intensive therapy, consisting of reintensification and addition of more drugs during maintenance, was reserved for high-risk and very-high-risk paitents. The overall survival and event-free survival (± 1 SE) were 70 ± 4.1% and 64 ± 4.3%, respectively, with follow-up ranging from 7.6 to 18.7 years (median 12.2 year). The isolated CNS relapse rate was 4.3%. The dropout rate significantaly decreased from 35% in 1982-1984 to 0% in 1991-1993. Although the patient population is small, the overall results for childhood ALL at the authors' hospital are encouraging as compared to earlier reports in Taiwan.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalPediatric Hematology and Oncology
Volume19
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

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Keywords

  • Acute lymphoblastic leukemia
  • Epirubicin
  • Long-term treatment results

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

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