Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas

S.-P. Huang, J. Chiou, Y.-H. Jan, T.-C. Lai, Y.-L. Yu, M. Hsiao, Y.-F. Lin

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Abstract

Lower grade gliomas (LGGs) have highly diverse clinical phenotypes. The histological grade and type are insufficient to accurately predict the clinical outcomes of patients with LGGs. Therefore, identification of biomarkers that can facilitate the prediction of clinical outcomes in LGGs is urgently needed. Gene expression of LOX has been identified as a biomarker for various cancers. However, the clinical significance of LOX expression in LGGs has not been investigated. In this study, we analyzed the glioma RNA-seq dataset from TCGA (The Cancer Genome atlas) and identified lysyl oxidase (LOX) as a potential biomarker for LGGs. Kaplan-Meier survival analysis revealed that high LOX expression is associated with worse overall survival and recurrence free survival in LGG patients. Besides, high LOX expression is associated with poor response to primary therapy, follow-up treatment, targeted molecular therapy, and radiation therapy. Univariate and multivariate Cox regression analyses further confirmed LOX expression as an independent prognostic factor for LGG patients. Finally, we observed that LOX expression is significantly correlated with EMT (epithelial to mesenchymal transition) and IDH1 status in LGGs. In conclusion, our analyses suggest that LOX expression is a potential biomarker for prognosis and therapeutic response in LGGs. © 2018
Original languageEnglish
Pages (from-to)619-627
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume501
Issue number3
DOIs
Publication statusPublished - 2018

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Keywords

  • Biomarker
  • EMT
  • IDH1
  • Lower grade gliomas (LGGs)
  • Lysyl oxidase (LOX)
  • TCGA
  • bevacizumab
  • isocitrate dehydrogenase 1
  • protein lysine 6 oxidase
  • adult
  • Article
  • cancer prognosis
  • cancer radiotherapy
  • cohort analysis
  • controlled study
  • epithelial mesenchymal transition
  • female
  • follow up
  • gene expression
  • gene mutation
  • genetic association
  • glioma
  • human
  • IDH1 gene
  • LOX gene
  • major clinical study
  • male
  • molecularly targeted therapy
  • overall survival
  • priority journal
  • recurrence free survival
  • RNA sequence
  • treatment response

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