Ovatodiolide suppresses allergic airway inflammation and hyperresponsiveness in a murine model of asthma

Chien Neng Wang, Yueh Lun Lee, Yu Pei Lin, Wen Hui Chung, Yew Min Tzeng, Chen Chen Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs.Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (TH2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed TH2 activation, including cell proliferation and production of the TH2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of TH2 responses in a murine model of asthma.

Original languageEnglish
JournalEuropean Journal of Pharmacology
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Asthma
Inflammation
Cytokines
Th2 Cells
Interleukin-13
Diterpenes
Drug and Narcotic Control
Interleukin-5
Ovalbumin
Bronchoalveolar Lavage Fluid
Therapeutics
Eosinophils
Interleukin-4
Pharmaceutical Preparations
Lung Diseases
Down-Regulation
Steroids
Cell Proliferation
ovatodiolide
Proteins

Keywords

  • Airway responsiveness
  • Allergic asthma
  • Ovatodiolide
  • T2 cell

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ovatodiolide suppresses allergic airway inflammation and hyperresponsiveness in a murine model of asthma. / Wang, Chien Neng; Lee, Yueh Lun; Lin, Yu Pei; Chung, Wen Hui; Tzeng, Yew Min; Lee, Chen Chen.

In: European Journal of Pharmacology, 2017.

Research output: Contribution to journalArticle

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AU - Tzeng, Yew Min

AU - Lee, Chen Chen

PY - 2017

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N2 - Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs.Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (TH2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed TH2 activation, including cell proliferation and production of the TH2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of TH2 responses in a murine model of asthma.

AB - Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs.Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (TH2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed TH2 activation, including cell proliferation and production of the TH2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of TH2 responses in a murine model of asthma.

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