TY - JOUR
T1 - Ovatodiolide suppresses allergic airway inflammation and hyperresponsiveness in a murine model of asthma
AU - Wang, Chien Neng
AU - Lee, Yueh Lun
AU - Lin, Yu Pei
AU - Chung, Wen Hui
AU - Tzeng, Yew Min
AU - Lee, Chen Chen
PY - 2017
Y1 - 2017
N2 - Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs.Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (TH2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed TH2 activation, including cell proliferation and production of the TH2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of TH2 responses in a murine model of asthma.
AB - Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs.Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (TH2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed TH2 activation, including cell proliferation and production of the TH2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of TH2 responses in a murine model of asthma.
KW - Airway responsiveness
KW - Allergic asthma
KW - Ovatodiolide
KW - T2 cell
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U2 - 10.1016/j.ejphar.2017.06.036
DO - 10.1016/j.ejphar.2017.06.036
M3 - Article
AN - SCOPUS:85021720636
SN - 0014-2999
VL - 812
SP - 9
EP - 17
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
ER -