Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration

Tsung Hsien Lee, Ming Yih Wu, Hsin Fu Chen, Mei Jou Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix.

Original languageEnglish
Pages (from-to)1700-1707
Number of pages8
JournalFertility and Sterility
Volume83
Issue number6
DOIs
Publication statusPublished - Jun 1 2005
Externally publishedYes

Fingerprint

Drug Administration Schedule
Hormone Antagonists
Ovarian Follicle
Ovulation Induction
Pregnancy Rate
Fertilization in Vitro
Chi-Square Distribution
Gonadotropin-Releasing Hormone
Analysis of Variance
Pregnancy
Buserelin
Intracytoplasmic Sperm Injections
Oocyte Retrieval
Zygote
Embryo Transfer
Serum
Estradiol
Randomized Controlled Trials
Outcome Assessment (Health Care)
cetrorelix

Keywords

  • Follicular development
  • GnRH agonist
  • GnRH antagonist
  • Multiple-dose protocol
  • Single-dose protocol

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration. / Lee, Tsung Hsien; Wu, Ming Yih; Chen, Hsin Fu; Chen, Mei Jou; Ho, Hong Nerng; Yang, Yu Shih.

In: Fertility and Sterility, Vol. 83, No. 6, 01.06.2005, p. 1700-1707.

Research output: Contribution to journalArticle

Lee, Tsung Hsien ; Wu, Ming Yih ; Chen, Hsin Fu ; Chen, Mei Jou ; Ho, Hong Nerng ; Yang, Yu Shih. / Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration. In: Fertility and Sterility. 2005 ; Vol. 83, No. 6. pp. 1700-1707.
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