Abstract
Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix.
| Original language | English |
|---|---|
| Pages (from-to) | 1700-1707 |
| Number of pages | 8 |
| Journal | Fertility and Sterility |
| Volume | 83 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2005 |
| Externally published | Yes |
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Keywords
- Follicular development
- GnRH agonist
- GnRH antagonist
- Multiple-dose protocol
- Single-dose protocol
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
Cite this
Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration. / Lee, Tsung Hsien; Wu, Ming Yih; Chen, Hsin Fu; Chen, Mei Jou; Ho, Hong Nerng; Yang, Yu Shih.
In: Fertility and Sterility, Vol. 83, No. 6, 01.06.2005, p. 1700-1707.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration
AU - Lee, Tsung Hsien
AU - Wu, Ming Yih
AU - Chen, Hsin Fu
AU - Chen, Mei Jou
AU - Ho, Hong Nerng
AU - Yang, Yu Shih
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix.
AB - Objective: To determine the efficiency of a single-dose and a multiple-dose protocol for GnRH antagonist administration. Design: Randomized clinical trial. Setting: University hospital, tertiary medical center. Patient(s): Sixty-one patients undergoing controlled ovarian stimulation (COS) and IVF/ICSI. Intervention(s): COS with either a multiple-dose (MD) or a single-dose (SD) protocol for GnRH antagonist (cetrorelix) administration, or with a long protocol (LP) for GnRH agonist (buserelin) administration, followed by oocyte retrieval, IVF/ICSI, and embryo transfer. Main Outcome Measure(s): Follicular development and serum levels of E2 and LH. Result(s): The SD protocol for cetrorelix was associated with a more reduced level of follicular development, lower levels of serum estradiol on the day of HCG administration, and a more reduced number of zygotes than the LP for buserelin. The pregnancy and implantation rates did not differ significantly for the three study groups. Conclusion(s): The MD and SD GnRH antagonist protocols were effective for preventing LH surge and appear to elicit an equivalent pregnancy rate to that corresponding to a LP GnRH agonist. In terms of follicular development, the SD protocol requires further modification, including flexible scheduling or possibly a small reduction of the dosage of the administered cetrorelix.
KW - Follicular development
KW - GnRH agonist
KW - GnRH antagonist
KW - Multiple-dose protocol
KW - Single-dose protocol
UR - http://www.scopus.com/inward/record.url?scp=20444494961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444494961&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2004.12.037
DO - 10.1016/j.fertnstert.2004.12.037
M3 - Article
C2 - 15950639
AN - SCOPUS:20444494961
VL - 83
SP - 1700
EP - 1707
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 6
ER -