Ovarian cancer and antidepressants

Chi Shin Wu, Mong Liang Lu, Yin To Liao, Charles Tzu Chi Lee, Vincent Chin Hung Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Abstract Background The association between antidepressant use and ovarian cancer remains unclear. This study aimed to assess the ovarian cancer risk with antidepressant use in the general population. Methods Taiwan's National Health Insurance Research Database was used to identify 957 patients with ovarian cancer and 9570 controls. We used a conditional logistic regression model for data analysis, excluding a 1-year latent period before the diagnosis of ovarian cancer to account for the quantification of treatment duration. Results We found no increased risk of developing ovarian cancer among antidepressant users. Neither the duration of antidepressant use nor the average dose had a significant effect on the risk of ovarian cancer. In addition, timing of antidepressant use was not linked to ovarian cancer risk. However, we found the estimate of ovarian cancer risk increased slightly among subjects under 50 years (adjusted OR = 2.03, 95% CI [0.82, 5.02]), although this association was still statistically insignificant (p = 0.12). Conclusions There was no association between risk of ovarian cancer and use of antidepressant drugs. Whether or not there is possible risk of using antidepressant whose mechanism of action involves dopamine and norepinephrine warrants further investigation.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalPsycho-Oncology
Volume24
Issue number5
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Ovarian Neoplasms
Antidepressive Agents
Logistic Models
National Health Programs
Taiwan
Dopamine
Norepinephrine
Databases
Research
Population

Keywords

  • Antidepressant
  • Depression
  • Oncology
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Psychiatry and Mental health
  • Experimental and Cognitive Psychology

Cite this

Wu, C. S., Lu, M. L., Liao, Y. T., Lee, C. T. C., & Chen, V. C. H. (2015). Ovarian cancer and antidepressants. Psycho-Oncology, 24(5), 579-584. https://doi.org/10.1002/pon.3700

Ovarian cancer and antidepressants. / Wu, Chi Shin; Lu, Mong Liang; Liao, Yin To; Lee, Charles Tzu Chi; Chen, Vincent Chin Hung.

In: Psycho-Oncology, Vol. 24, No. 5, 01.05.2015, p. 579-584.

Research output: Contribution to journalArticle

Wu, CS, Lu, ML, Liao, YT, Lee, CTC & Chen, VCH 2015, 'Ovarian cancer and antidepressants', Psycho-Oncology, vol. 24, no. 5, pp. 579-584. https://doi.org/10.1002/pon.3700
Wu CS, Lu ML, Liao YT, Lee CTC, Chen VCH. Ovarian cancer and antidepressants. Psycho-Oncology. 2015 May 1;24(5):579-584. https://doi.org/10.1002/pon.3700
Wu, Chi Shin ; Lu, Mong Liang ; Liao, Yin To ; Lee, Charles Tzu Chi ; Chen, Vincent Chin Hung. / Ovarian cancer and antidepressants. In: Psycho-Oncology. 2015 ; Vol. 24, No. 5. pp. 579-584.
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