Outcome of patients with recurrent adult-type granulosa cell tumors - A Taiwanese Gynecologic Oncology Group study

Peng Hui Wang, Hsu Dong Sun, Hao Lin, Kung Liahng Wang, Wen Shiung Liou, Yao Ching Hung, Ying Cheng Chiang, Chien Hsing Lu, Hung Cheng Lai, Ting Chang Chang, Ming Shyen Yen, Chi An Chen, Chyong Hyeu Lai, Mu Shyen Yu, Cheng Yang Chou, Chi Lun Chang, Kuo Feng Huang, Chih Ming Ho, Tan Yuan Chu, Po Hui WangFu Shing Liu, Yuen Yee Kan, Ching Hu Wu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The aim of this study is to evaluate the long-term outcome of ovarian recurrent granulosa cell tumors (GCTs) in a large series of patients treated in Taiwanese Gynecologic Oncology Group (TGOG) centers and to define the prognostic parameters for survival. Materials and methods: A retrospective multi-institutional review of patients with recurrent ovarian GCTs treated in TGOG centers was conducted. The clinical and pathological characteristics, treatment, and outcomes of patients with ovarian recurrent GCTs were analyzed using Kaplan-Meier and Cox proportional hazards analyses to determine the predictors for survival. Results: A total of 44 patients from 16 medical centers were identified between January 1994 and December 2010. The median disease-free survival (DFS), postrecurrence survival, and overall survival (OS) were 61.5 months (range, 3.7-219.3 months), 55.8 months (range, 4.6-193.7 months), and 115.3 months (range, 17.2-390.6 months), respectively. In multivariate analysis, DFS (> 61.5 months versus ≤ 61.5 months, hazard ratio (HR) 0.15, 95% confidence interval (CI) 0.03-0.78, p = 0.024) at the initial operation after diagnosis of relapse was the only predictor that correlated with OS. Conclusion: DFS after the initial operation was the only important predictor for overall survival in patients with recurrent GCTs, regardless of treatment, suggesting that the natural behavior of the tumor is a critical factor for patients with recurrent GCTs.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume54
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Granulosa Cell Tumor
Survival
Disease-Free Survival
Multivariate Analysis
Confidence Intervals
Recurrence
Neoplasms

Keywords

  • Adult granulosa cell tumor
  • Ovarian granulosa cell tumor
  • Recurrent granulosa cell tumor
  • Recurrent ovarian neoplasm
  • Survival outcome
  • Taiwanese Gynecologic Oncology Group

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Outcome of patients with recurrent adult-type granulosa cell tumors - A Taiwanese Gynecologic Oncology Group study. / Wang, Peng Hui; Sun, Hsu Dong; Lin, Hao; Wang, Kung Liahng; Liou, Wen Shiung; Hung, Yao Ching; Chiang, Ying Cheng; Lu, Chien Hsing; Lai, Hung Cheng; Chang, Ting Chang; Yen, Ming Shyen; Chen, Chi An; Lai, Chyong Hyeu; Yu, Mu Shyen; Chou, Cheng Yang; Chang, Chi Lun; Huang, Kuo Feng; Ho, Chih Ming; Chu, Tan Yuan; Wang, Po Hui; Liu, Fu Shing; Kan, Yuen Yee; Wu, Ching Hu.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 54, No. 3, 2015, p. 253-259.

Research output: Contribution to journalArticle

Wang, PH, Sun, HD, Lin, H, Wang, KL, Liou, WS, Hung, YC, Chiang, YC, Lu, CH, Lai, HC, Chang, TC, Yen, MS, Chen, CA, Lai, CH, Yu, MS, Chou, CY, Chang, CL, Huang, KF, Ho, CM, Chu, TY, Wang, PH, Liu, FS, Kan, YY & Wu, CH 2015, 'Outcome of patients with recurrent adult-type granulosa cell tumors - A Taiwanese Gynecologic Oncology Group study', Taiwanese Journal of Obstetrics and Gynecology, vol. 54, no. 3, pp. 253-259. https://doi.org/10.1016/j.tjog.2014.12.007
Wang, Peng Hui ; Sun, Hsu Dong ; Lin, Hao ; Wang, Kung Liahng ; Liou, Wen Shiung ; Hung, Yao Ching ; Chiang, Ying Cheng ; Lu, Chien Hsing ; Lai, Hung Cheng ; Chang, Ting Chang ; Yen, Ming Shyen ; Chen, Chi An ; Lai, Chyong Hyeu ; Yu, Mu Shyen ; Chou, Cheng Yang ; Chang, Chi Lun ; Huang, Kuo Feng ; Ho, Chih Ming ; Chu, Tan Yuan ; Wang, Po Hui ; Liu, Fu Shing ; Kan, Yuen Yee ; Wu, Ching Hu. / Outcome of patients with recurrent adult-type granulosa cell tumors - A Taiwanese Gynecologic Oncology Group study. In: Taiwanese Journal of Obstetrics and Gynecology. 2015 ; Vol. 54, No. 3. pp. 253-259.
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AU - Wang, Peng Hui

AU - Sun, Hsu Dong

AU - Lin, Hao

AU - Wang, Kung Liahng

AU - Liou, Wen Shiung

AU - Hung, Yao Ching

AU - Chiang, Ying Cheng

AU - Lu, Chien Hsing

AU - Lai, Hung Cheng

AU - Chang, Ting Chang

AU - Yen, Ming Shyen

AU - Chen, Chi An

AU - Lai, Chyong Hyeu

AU - Yu, Mu Shyen

AU - Chou, Cheng Yang

AU - Chang, Chi Lun

AU - Huang, Kuo Feng

AU - Ho, Chih Ming

AU - Chu, Tan Yuan

AU - Wang, Po Hui

AU - Liu, Fu Shing

AU - Kan, Yuen Yee

AU - Wu, Ching Hu

PY - 2015

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N2 - Objective: The aim of this study is to evaluate the long-term outcome of ovarian recurrent granulosa cell tumors (GCTs) in a large series of patients treated in Taiwanese Gynecologic Oncology Group (TGOG) centers and to define the prognostic parameters for survival. Materials and methods: A retrospective multi-institutional review of patients with recurrent ovarian GCTs treated in TGOG centers was conducted. The clinical and pathological characteristics, treatment, and outcomes of patients with ovarian recurrent GCTs were analyzed using Kaplan-Meier and Cox proportional hazards analyses to determine the predictors for survival. Results: A total of 44 patients from 16 medical centers were identified between January 1994 and December 2010. The median disease-free survival (DFS), postrecurrence survival, and overall survival (OS) were 61.5 months (range, 3.7-219.3 months), 55.8 months (range, 4.6-193.7 months), and 115.3 months (range, 17.2-390.6 months), respectively. In multivariate analysis, DFS (> 61.5 months versus ≤ 61.5 months, hazard ratio (HR) 0.15, 95% confidence interval (CI) 0.03-0.78, p = 0.024) at the initial operation after diagnosis of relapse was the only predictor that correlated with OS. Conclusion: DFS after the initial operation was the only important predictor for overall survival in patients with recurrent GCTs, regardless of treatment, suggesting that the natural behavior of the tumor is a critical factor for patients with recurrent GCTs.

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KW - Adult granulosa cell tumor

KW - Ovarian granulosa cell tumor

KW - Recurrent granulosa cell tumor

KW - Recurrent ovarian neoplasm

KW - Survival outcome

KW - Taiwanese Gynecologic Oncology Group

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