Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan

Wen Cheng Chao; Yi Wen Huang; Ming Chih Yu; Wen Ta Yang; Chou Jui Lin; Jen Jyh Lee; Ruay Ming Huang; Chi Chang Shieh; Shun Tien Chien; Jung Yien Chien

doi:10.1186/s12879-015-0795-1

Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan

Wen Cheng Chao, Yi Wen Huang, Ming Chih Yu, Wen Ta Yang, Chou Jui Lin, Jen Jyh Lee, Ruay Ming Huang, Chi Chang Shieh, Shun Tien Chien, Jung Yien Chien

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

The appearance of smear-positivity but culture-negativity (SPCN) for acid-fast bacilli among sputum specimen is frequently found in pulmonary tuberculosis (TB) patients during treatment. This study aimed to investigate clinical risk factors, impacts on treatment course, and relapse pattern associated with sputum SPCN. Methods: We retrospectively enrolled 800 patients with culture-proven pulmonary TB who were receiving standard treatment and follow-up at six TB-referral hospitals in Taiwan between January 2006 and December 2007. Relevant patient characteristics and chemotherapy data were analyzed for associations with incidence of SPCN. Data from patients who relapsed within 3 years after completing treatment were analyzed for associations with SPCN during treatment. Results: Of the 800 subjects, 111 (13.8%) had sputum SPCN during treatment. Three factors were found to predict the development of SPCN; namely, high initial acid-fast staining grading (OR, 3.407; 95% CI, 2.090-5.553), cavitation on chest-X ray films (OR, 2.217; 95% CI, 1.359-3.615), and smoking (OR, 1.609; 95% CI, 1.006-2.841). Patients with SPCN had longer treatment duration (rifampicin: 284 ± 91 vs. 235 ± 69 days,

Original language	English
Article number	67
Journal	BMC Infectious Diseases
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12879-015-0795-1
Publication status	Published - Feb 18 2015

Keywords

Cavity
Relapse
Severity
Treatment
Tuberculosis

ASJC Scopus subject areas

Infectious Diseases

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Chao, W. C., Huang, Y. W., Yu, M. C., Yang, W. T., Lin, C. J., Lee, J. J., Huang, R. M., Shieh, C. C., Chien, S. T., & Chien, J. Y. (2015). Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan. BMC Infectious Diseases, 15(1), [67]. https://doi.org/10.1186/s12879-015-0795-1

Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan. / Chao, Wen Cheng; Huang, Yi Wen; Yu, Ming Chih; Yang, Wen Ta; Lin, Chou Jui; Lee, Jen Jyh; Huang, Ruay Ming; Shieh, Chi Chang; Chien, Shun Tien; Chien, Jung Yien.

In: BMC Infectious Diseases, Vol. 15, No. 1, 67, 18.02.2015.

Research output: Contribution to journal › Article

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abstract = "The appearance of smear-positivity but culture-negativity (SPCN) for acid-fast bacilli among sputum specimen is frequently found in pulmonary tuberculosis (TB) patients during treatment. This study aimed to investigate clinical risk factors, impacts on treatment course, and relapse pattern associated with sputum SPCN. Methods: We retrospectively enrolled 800 patients with culture-proven pulmonary TB who were receiving standard treatment and follow-up at six TB-referral hospitals in Taiwan between January 2006 and December 2007. Relevant patient characteristics and chemotherapy data were analyzed for associations with incidence of SPCN. Data from patients who relapsed within 3 years after completing treatment were analyzed for associations with SPCN during treatment. Results: Of the 800 subjects, 111 (13.8%) had sputum SPCN during treatment. Three factors were found to predict the development of SPCN; namely, high initial acid-fast staining grading (OR, 3.407; 95% CI, 2.090-5.553), cavitation on chest-X ray films (OR, 2.217; 95% CI, 1.359-3.615), and smoking (OR, 1.609; 95% CI, 1.006-2.841). Patients with SPCN had longer treatment duration (rifampicin: 284 ± 91 vs. 235 ± 69 days, ",

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