Abstract

Background: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. Results: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p <0 .01). Conclusion: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.

Original languageEnglish
Article number192
JournalBMC Gastroenterology
Volume14
Issue number1
DOIs
Publication statusPublished - Nov 18 2014

Fingerprint

Gallstones
Taiwan
Osteoporosis
Cohort Studies
Population
Regression Analysis
Osteopontin
Bone Remodeling
National Health Programs
Osteoclasts
Bone Resorption
Survival Rate
Cholesterol
Databases
Confidence Intervals
Cytokines
Research
Proteins

Keywords

  • Gallstone
  • Osteoporosis
  • Population-based study
  • Taiwan

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Osteoporosis increases subsequent risk of gallstone : A nationwide population-based cohort study in Taiwan. / Klahan, Sukhontip; Kuo, Chun Nan; Chien, Shu-Chen; Lin, Yea Wen; Lin, Chun Yi; Lin, Chia Hsien; Chang, Wei Chiao; Lin, Ching I.; Hung, Kuo Sheng; Chang, Wei Pin.

In: BMC Gastroenterology, Vol. 14, No. 1, 192, 18.11.2014.

Research output: Contribution to journalArticle

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abstract = "Background: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. Results: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95{\%} confidence interval: 1.07 - 1.69; p <0 .01). Conclusion: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.",
keywords = "Gallstone, Osteoporosis, Population-based study, Taiwan",
author = "Sukhontip Klahan and Kuo, {Chun Nan} and Shu-Chen Chien and Lin, {Yea Wen} and Lin, {Chun Yi} and Lin, {Chia Hsien} and Chang, {Wei Chiao} and Lin, {Ching I.} and Hung, {Kuo Sheng} and Chang, {Wei Pin}",
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AU - Klahan, Sukhontip

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AU - Chien, Shu-Chen

AU - Lin, Yea Wen

AU - Lin, Chun Yi

AU - Lin, Chia Hsien

AU - Chang, Wei Chiao

AU - Lin, Ching I.

AU - Hung, Kuo Sheng

AU - Chang, Wei Pin

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N2 - Background: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. Results: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p <0 .01). Conclusion: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.

AB - Background: Osteopontin (OPN) is a pro-inflammatory cytokine which is expressed in various tissues. It participates in the bone remodeling process and stimulates bone resorption by osteoclasts. It is also a core protein of cholesterol gallstones. We hypothesized osteoporotic patients might have higher risk in developing gallstones and conducted a population-based study to examine the risk of developing gallstone in osteoporotic patients in Taiwan. Methods: A total of 1,638 patients diagnosed with osteoporosis between 2003 and 2005 were identified in the National Health Insurance Research Database. A comparison cohort without osteoporosis (n =6,552) was randomly matched to each osteoporosis patient at a ratio of 4: 1 based on age and sex. A Cox proportional-hazards regression analysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts. Results: During the 5-year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison cohorts, respectively. After adjusting for the confounders, the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yielded a hazard ratio of 1.35 (95% confidence interval: 1.07 - 1.69; p <0 .01). Conclusion: Patients with osteoporosis in Taiwan have a higher risk of developing gallstone than the general population.

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