Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas

Kuan Yin Tseng, Min Huey Chung, Huey Kang Sytwu, Horng Mo Lee, Kuan Yu Chen, Chen Chang, Chih Kung Lin, Che Hung Yen, Jia Hong Chen, Gu Jiun Lin, Hsin I. Ma, Yi Shian Yeh, Da Tong Ju, Ming Ying Liu, Dueng Yuan Hueng

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Prediction of recurrence remains a challenge in histopathological benign/grade I tumors. Osteopontin (OPN) plays important roles in tumorigenesis, invasion, and metastasis of several human cancers. In this study, we investigated OPN protein expression by evaluating the differences between recurrent and non-recurrent histologically benign meningiomas. Thirty-two patients were enrolled, and 23 benign non-recurrent meningiomas and 9 benign recurrent meningiomas were followed for a mean of 34 months after complete surgical resection (Simpson grades I and II). Cytoplasmic OPN staining was evaluated by means of immunohistochemistry (IHC) score and by use of the Allred-8-unit system. We examined clinical biological data, their relationship with tumor recurrence, and the expression of OPN. Our results showed that meningioma recurrence correlated significantly with OPN IHC score (P = 0.001). An OPN Allred score between 0 and 3 was associated with a recurrence-free time of more than 25 months. In comparison, an OPN Allred score from 4 to 8 was indicative of a shorter average recurrence-free time. We concluded that OPN IHC score may play a role in prediction of the recurrence of the grade I meningiomas. Moreover, determination of the OPN Allred score is a reliable, quantitative tool for predicting recurrence-free time in benign meningioma patients.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalJournal of Neuro-Oncology
Volume100
Issue number2
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Osteopontin
Meningioma
Recurrence
Immunohistochemistry
Neoplasms
Carcinogenesis
Staining and Labeling
Neoplasm Metastasis

Keywords

  • Allred score
  • Immunohistochemical staining
  • Meningioma
  • Osteopontin
  • Recurrence

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. / Tseng, Kuan Yin; Chung, Min Huey; Sytwu, Huey Kang; Lee, Horng Mo; Chen, Kuan Yu; Chang, Chen; Lin, Chih Kung; Yen, Che Hung; Chen, Jia Hong; Lin, Gu Jiun; Ma, Hsin I.; Yeh, Yi Shian; Ju, Da Tong; Liu, Ming Ying; Hueng, Dueng Yuan.

In: Journal of Neuro-Oncology, Vol. 100, No. 2, 11.2010, p. 217-223.

Research output: Contribution to journalArticle

Tseng, KY, Chung, MH, Sytwu, HK, Lee, HM, Chen, KY, Chang, C, Lin, CK, Yen, CH, Chen, JH, Lin, GJ, Ma, HI, Yeh, YS, Ju, DT, Liu, MY & Hueng, DY 2010, 'Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas', Journal of Neuro-Oncology, vol. 100, no. 2, pp. 217-223. https://doi.org/10.1007/s11060-010-0164-2
Tseng, Kuan Yin ; Chung, Min Huey ; Sytwu, Huey Kang ; Lee, Horng Mo ; Chen, Kuan Yu ; Chang, Chen ; Lin, Chih Kung ; Yen, Che Hung ; Chen, Jia Hong ; Lin, Gu Jiun ; Ma, Hsin I. ; Yeh, Yi Shian ; Ju, Da Tong ; Liu, Ming Ying ; Hueng, Dueng Yuan. / Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas. In: Journal of Neuro-Oncology. 2010 ; Vol. 100, No. 2. pp. 217-223.
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AU - Lin, Chih Kung

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AU - Yeh, Yi Shian

AU - Ju, Da Tong

AU - Liu, Ming Ying

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