The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.
- Bone marrow transplantation
- Bone-specific alkaline phosphatase
- Malignant infantile osteopetrosis
- Tartrate-resistant acid phosphatase 5b
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health