Osteoblast and Osteoclast Activity in a Malignant Infantile Osteopetrosis Patient Following Bone Marrow Transplantation

Chun Jung Chen, Tsu Yi Chao, Der Ming Chu, Anthony J. Janckila, Shin Nan Cheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2004
Externally publishedYes

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Keywords

  • Bone marrow transplantation
  • Bone-specific alkaline phosphatase
  • Children
  • Malignant infantile osteopetrosis
  • Tartrate-resistant acid phosphatase 5b

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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