Orbitofrontal cortical dysfunction in akinetic catatonia

A functional magnetic resonance imaging study during negative emotional stimulation

Georg Northoff, Rolf Kötter, Frank Baumgart, Peter Danos, Heinz Boeker, Thomas Kaulisch, Florian Schlagenhauf, Henrik Walter, Alexander Heinzel, Thómas Witzel, Bernhard Bogerts

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Catatonia is a psychomotor syndrome characterized by concurrent emotional, behavioral, and motor anomalies. Pathophysiological mechanisms of psychomotor disturbances may be related to abnormal emotional-motor processing in prefrontal cortical networks. We therefore investigated prefrontal cortical activation and connectivity patterns during emotional-motor stimulation using functional magnetic resonance imaging (FMRI). We investigated 10 akinetic catatonic patients in a postacute state and compared them with 10 noncatatonic postacute psychiatric controls (age-, sex-, diagnosis-, and medication-matched) and 10 healthy controls. Positive and negative pictures from the International Affective Picture System were used for emotional stimulation. FMRI measurements covered the whole frontal lobe, activation signals in various frontal cortical regions were obtained, and functional connectivity between the different prefrontal cortical regions was investigated using structural equation modeling. Catatonic patients showed alterations in the orbitofrontal cortical activation pattern and in functional connectivity to the premotor cortex in negative and positive emotions compared to psychiatric and healthy controls. Catatonic behavioral and affective symptoms correlated significantly with orbitofrontal activity, whereas catatonic motor symptoms were rather related to medial prefrontal activity. It is concluded that catatonic symptoms may be closely related to dysfunction in the orbitofrontal cortex and consequent alteration in the prefrontal cortical network during emotional processing. Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis.

Original languageEnglish
Pages (from-to)405-427
Number of pages23
JournalSchizophrenia Bulletin
Volume30
Issue number2
Publication statusPublished - 2004

Fingerprint

Catatonia
Magnetic Resonance Imaging
Psychiatry
Psychotic Affective Disorders
Behavioral Symptoms
Affective Symptoms
Motor Cortex
Frontal Lobe
Prefrontal Cortex
Emotions

Keywords

  • Catatonia
  • Effective connectivity
  • Emotions
  • FMRI
  • Orbitofrontal cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Orbitofrontal cortical dysfunction in akinetic catatonia : A functional magnetic resonance imaging study during negative emotional stimulation. / Northoff, Georg; Kötter, Rolf; Baumgart, Frank; Danos, Peter; Boeker, Heinz; Kaulisch, Thomas; Schlagenhauf, Florian; Walter, Henrik; Heinzel, Alexander; Witzel, Thómas; Bogerts, Bernhard.

In: Schizophrenia Bulletin, Vol. 30, No. 2, 2004, p. 405-427.

Research output: Contribution to journalArticle

Northoff, G, Kötter, R, Baumgart, F, Danos, P, Boeker, H, Kaulisch, T, Schlagenhauf, F, Walter, H, Heinzel, A, Witzel, T & Bogerts, B 2004, 'Orbitofrontal cortical dysfunction in akinetic catatonia: A functional magnetic resonance imaging study during negative emotional stimulation', Schizophrenia Bulletin, vol. 30, no. 2, pp. 405-427.
Northoff, Georg ; Kötter, Rolf ; Baumgart, Frank ; Danos, Peter ; Boeker, Heinz ; Kaulisch, Thomas ; Schlagenhauf, Florian ; Walter, Henrik ; Heinzel, Alexander ; Witzel, Thómas ; Bogerts, Bernhard. / Orbitofrontal cortical dysfunction in akinetic catatonia : A functional magnetic resonance imaging study during negative emotional stimulation. In: Schizophrenia Bulletin. 2004 ; Vol. 30, No. 2. pp. 405-427.
@article{1f43d14e7bd54688a70b034931a5f3f9,
title = "Orbitofrontal cortical dysfunction in akinetic catatonia: A functional magnetic resonance imaging study during negative emotional stimulation",
abstract = "Catatonia is a psychomotor syndrome characterized by concurrent emotional, behavioral, and motor anomalies. Pathophysiological mechanisms of psychomotor disturbances may be related to abnormal emotional-motor processing in prefrontal cortical networks. We therefore investigated prefrontal cortical activation and connectivity patterns during emotional-motor stimulation using functional magnetic resonance imaging (FMRI). We investigated 10 akinetic catatonic patients in a postacute state and compared them with 10 noncatatonic postacute psychiatric controls (age-, sex-, diagnosis-, and medication-matched) and 10 healthy controls. Positive and negative pictures from the International Affective Picture System were used for emotional stimulation. FMRI measurements covered the whole frontal lobe, activation signals in various frontal cortical regions were obtained, and functional connectivity between the different prefrontal cortical regions was investigated using structural equation modeling. Catatonic patients showed alterations in the orbitofrontal cortical activation pattern and in functional connectivity to the premotor cortex in negative and positive emotions compared to psychiatric and healthy controls. Catatonic behavioral and affective symptoms correlated significantly with orbitofrontal activity, whereas catatonic motor symptoms were rather related to medial prefrontal activity. It is concluded that catatonic symptoms may be closely related to dysfunction in the orbitofrontal cortex and consequent alteration in the prefrontal cortical network during emotional processing. Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis.",
keywords = "Catatonia, Effective connectivity, Emotions, FMRI, Orbitofrontal cortex",
author = "Georg Northoff and Rolf K{\"o}tter and Frank Baumgart and Peter Danos and Heinz Boeker and Thomas Kaulisch and Florian Schlagenhauf and Henrik Walter and Alexander Heinzel and Th{\'o}mas Witzel and Bernhard Bogerts",
year = "2004",
language = "English",
volume = "30",
pages = "405--427",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Orbitofrontal cortical dysfunction in akinetic catatonia

T2 - A functional magnetic resonance imaging study during negative emotional stimulation

AU - Northoff, Georg

AU - Kötter, Rolf

AU - Baumgart, Frank

AU - Danos, Peter

AU - Boeker, Heinz

AU - Kaulisch, Thomas

AU - Schlagenhauf, Florian

AU - Walter, Henrik

AU - Heinzel, Alexander

AU - Witzel, Thómas

AU - Bogerts, Bernhard

PY - 2004

Y1 - 2004

N2 - Catatonia is a psychomotor syndrome characterized by concurrent emotional, behavioral, and motor anomalies. Pathophysiological mechanisms of psychomotor disturbances may be related to abnormal emotional-motor processing in prefrontal cortical networks. We therefore investigated prefrontal cortical activation and connectivity patterns during emotional-motor stimulation using functional magnetic resonance imaging (FMRI). We investigated 10 akinetic catatonic patients in a postacute state and compared them with 10 noncatatonic postacute psychiatric controls (age-, sex-, diagnosis-, and medication-matched) and 10 healthy controls. Positive and negative pictures from the International Affective Picture System were used for emotional stimulation. FMRI measurements covered the whole frontal lobe, activation signals in various frontal cortical regions were obtained, and functional connectivity between the different prefrontal cortical regions was investigated using structural equation modeling. Catatonic patients showed alterations in the orbitofrontal cortical activation pattern and in functional connectivity to the premotor cortex in negative and positive emotions compared to psychiatric and healthy controls. Catatonic behavioral and affective symptoms correlated significantly with orbitofrontal activity, whereas catatonic motor symptoms were rather related to medial prefrontal activity. It is concluded that catatonic symptoms may be closely related to dysfunction in the orbitofrontal cortex and consequent alteration in the prefrontal cortical network during emotional processing. Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis.

AB - Catatonia is a psychomotor syndrome characterized by concurrent emotional, behavioral, and motor anomalies. Pathophysiological mechanisms of psychomotor disturbances may be related to abnormal emotional-motor processing in prefrontal cortical networks. We therefore investigated prefrontal cortical activation and connectivity patterns during emotional-motor stimulation using functional magnetic resonance imaging (FMRI). We investigated 10 akinetic catatonic patients in a postacute state and compared them with 10 noncatatonic postacute psychiatric controls (age-, sex-, diagnosis-, and medication-matched) and 10 healthy controls. Positive and negative pictures from the International Affective Picture System were used for emotional stimulation. FMRI measurements covered the whole frontal lobe, activation signals in various frontal cortical regions were obtained, and functional connectivity between the different prefrontal cortical regions was investigated using structural equation modeling. Catatonic patients showed alterations in the orbitofrontal cortical activation pattern and in functional connectivity to the premotor cortex in negative and positive emotions compared to psychiatric and healthy controls. Catatonic behavioral and affective symptoms correlated significantly with orbitofrontal activity, whereas catatonic motor symptoms were rather related to medial prefrontal activity. It is concluded that catatonic symptoms may be closely related to dysfunction in the orbitofrontal cortex and consequent alteration in the prefrontal cortical network during emotional processing. Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis.

KW - Catatonia

KW - Effective connectivity

KW - Emotions

KW - FMRI

KW - Orbitofrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=3042578360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042578360&partnerID=8YFLogxK

M3 - Article

VL - 30

SP - 405

EP - 427

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 2

ER -