Orbital hemangiopericytoma in an Asian population

Chi Hsin Hsu, Yi Hsuan Wei, Yeh Peng, Shu Lang Liao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose: Hemangiopericytoma is a very rare orbital tumor. The purpose of this study was to report the clinical and histopathological features of six cases of orbital hemangiopericytoma in an Asian population. Methods: Clinical and histopathological features were reviewed in six patients who were histopathologically confirmed as having primary orbital hemangiopericytoma in National Taiwan University Hospital between May 2001 and December 2010. Results: Among the six cases who were diagnosed as having primary orbital hemangiopericytoma, all lesions were reported as vascular tumors and featured branching "staghorn appearance" vessels. All patients, including one male and five females, presented with progressive proptosis and some associated symptoms such as extraocular motility limitation with diplopia, displacement of the globe, afferent pupillary defect, congested vessels of conjunctiva, or decreased visual acuity. On computed tomography, the orbital tumors tended to manifest as circumscribed masses with homogeneous medium-to-high enhancement with contrast studies. All six patients received surgical treatments, and four of them had additional radiotherapy. Three patients had recurrence after surgeries, and one of them had multiple metastases to lung and liver. All patients were still alive after a follow-up period of 5-10 years. Conclusion: Orbital hemangiopericytoma has malignant potential, which may lead to local recurrence and/or metastasis. Histopathological findings alone are insufficient to predict the behavior of this tumor. Therefore, both clinical and histopathological findings are important to evaluate the treatment outcomes. Total excision accompanied with radiotherapy is suggested and long-term follow-up is required.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalJournal of the Formosan Medical Association
Volume113
Issue number6
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Hemangiopericytoma
Population
Neoplasms
Radiotherapy
Pupil Disorders
Neoplasm Metastasis
Recurrence
Exophthalmos
Diplopia
Conjunctiva
Taiwan
Visual Acuity
Blood Vessels
Tomography
Lung
Liver

Keywords

  • Asian population
  • Orbital hemangio-pericytoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orbital hemangiopericytoma in an Asian population. / Hsu, Chi Hsin; Wei, Yi Hsuan; Peng, Yeh; Liao, Shu Lang.

In: Journal of the Formosan Medical Association, Vol. 113, No. 6, 01.01.2014, p. 356-363.

Research output: Contribution to journalArticle

Hsu, Chi Hsin ; Wei, Yi Hsuan ; Peng, Yeh ; Liao, Shu Lang. / Orbital hemangiopericytoma in an Asian population. In: Journal of the Formosan Medical Association. 2014 ; Vol. 113, No. 6. pp. 356-363.
@article{1cc83002457247d296587b3d8ae0d45b,
title = "Orbital hemangiopericytoma in an Asian population",
abstract = "Background/Purpose: Hemangiopericytoma is a very rare orbital tumor. The purpose of this study was to report the clinical and histopathological features of six cases of orbital hemangiopericytoma in an Asian population. Methods: Clinical and histopathological features were reviewed in six patients who were histopathologically confirmed as having primary orbital hemangiopericytoma in National Taiwan University Hospital between May 2001 and December 2010. Results: Among the six cases who were diagnosed as having primary orbital hemangiopericytoma, all lesions were reported as vascular tumors and featured branching {"}staghorn appearance{"} vessels. All patients, including one male and five females, presented with progressive proptosis and some associated symptoms such as extraocular motility limitation with diplopia, displacement of the globe, afferent pupillary defect, congested vessels of conjunctiva, or decreased visual acuity. On computed tomography, the orbital tumors tended to manifest as circumscribed masses with homogeneous medium-to-high enhancement with contrast studies. All six patients received surgical treatments, and four of them had additional radiotherapy. Three patients had recurrence after surgeries, and one of them had multiple metastases to lung and liver. All patients were still alive after a follow-up period of 5-10 years. Conclusion: Orbital hemangiopericytoma has malignant potential, which may lead to local recurrence and/or metastasis. Histopathological findings alone are insufficient to predict the behavior of this tumor. Therefore, both clinical and histopathological findings are important to evaluate the treatment outcomes. Total excision accompanied with radiotherapy is suggested and long-term follow-up is required.",
keywords = "Asian population, Orbital hemangio-pericytoma",
author = "Hsu, {Chi Hsin} and Wei, {Yi Hsuan} and Yeh Peng and Liao, {Shu Lang}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.jfma.2012.08.004",
language = "English",
volume = "113",
pages = "356--363",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - Orbital hemangiopericytoma in an Asian population

AU - Hsu, Chi Hsin

AU - Wei, Yi Hsuan

AU - Peng, Yeh

AU - Liao, Shu Lang

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background/Purpose: Hemangiopericytoma is a very rare orbital tumor. The purpose of this study was to report the clinical and histopathological features of six cases of orbital hemangiopericytoma in an Asian population. Methods: Clinical and histopathological features were reviewed in six patients who were histopathologically confirmed as having primary orbital hemangiopericytoma in National Taiwan University Hospital between May 2001 and December 2010. Results: Among the six cases who were diagnosed as having primary orbital hemangiopericytoma, all lesions were reported as vascular tumors and featured branching "staghorn appearance" vessels. All patients, including one male and five females, presented with progressive proptosis and some associated symptoms such as extraocular motility limitation with diplopia, displacement of the globe, afferent pupillary defect, congested vessels of conjunctiva, or decreased visual acuity. On computed tomography, the orbital tumors tended to manifest as circumscribed masses with homogeneous medium-to-high enhancement with contrast studies. All six patients received surgical treatments, and four of them had additional radiotherapy. Three patients had recurrence after surgeries, and one of them had multiple metastases to lung and liver. All patients were still alive after a follow-up period of 5-10 years. Conclusion: Orbital hemangiopericytoma has malignant potential, which may lead to local recurrence and/or metastasis. Histopathological findings alone are insufficient to predict the behavior of this tumor. Therefore, both clinical and histopathological findings are important to evaluate the treatment outcomes. Total excision accompanied with radiotherapy is suggested and long-term follow-up is required.

AB - Background/Purpose: Hemangiopericytoma is a very rare orbital tumor. The purpose of this study was to report the clinical and histopathological features of six cases of orbital hemangiopericytoma in an Asian population. Methods: Clinical and histopathological features were reviewed in six patients who were histopathologically confirmed as having primary orbital hemangiopericytoma in National Taiwan University Hospital between May 2001 and December 2010. Results: Among the six cases who were diagnosed as having primary orbital hemangiopericytoma, all lesions were reported as vascular tumors and featured branching "staghorn appearance" vessels. All patients, including one male and five females, presented with progressive proptosis and some associated symptoms such as extraocular motility limitation with diplopia, displacement of the globe, afferent pupillary defect, congested vessels of conjunctiva, or decreased visual acuity. On computed tomography, the orbital tumors tended to manifest as circumscribed masses with homogeneous medium-to-high enhancement with contrast studies. All six patients received surgical treatments, and four of them had additional radiotherapy. Three patients had recurrence after surgeries, and one of them had multiple metastases to lung and liver. All patients were still alive after a follow-up period of 5-10 years. Conclusion: Orbital hemangiopericytoma has malignant potential, which may lead to local recurrence and/or metastasis. Histopathological findings alone are insufficient to predict the behavior of this tumor. Therefore, both clinical and histopathological findings are important to evaluate the treatment outcomes. Total excision accompanied with radiotherapy is suggested and long-term follow-up is required.

KW - Asian population

KW - Orbital hemangio-pericytoma

UR - http://www.scopus.com/inward/record.url?scp=84899946691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899946691&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2012.08.004

DO - 10.1016/j.jfma.2012.08.004

M3 - Article

C2 - 24820631

AN - SCOPUS:84899946691

VL - 113

SP - 356

EP - 363

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 6

ER -