Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice

Hui Yu Huang, Shih Yung Chieh, Tim K. Tso, Ting Yi Chien, Hsin Tang Lin, Ying Chieh Tsai

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Aim of the study: The aim of this study was to evaluate the anticancer effect of a mycelial culture from Phellinus linteus PL-7 (MCPL-7) and to elucidate its potential mechanism in vivo. Materials and methods: SCID CB-17 mice received a transplant of Hep3B cells followed by daily MCPL-7 administrations for 8 weeks. Following tumor implantation, groups C-E were subcutaneously administered 50 mg/kg, 100 mg/kg, or 250 mg/kg MCPL-7 powder per day, respectively, for 8 weeks. Groups A and B received saline solution subcutaneously for 8 weeks. Results: MCPL-7 administration induced a significant reduction in tumor size and was associated with a significant increase in T cell numbers; IL-12, IFN-γ and TNF-α secretion; NK cell activity; and phagocytic ability. Therefore, increased numbers of CD4+cells could have been caused by greater numbers of dendritic cells and macrophages in the spleen. Furthermore, the activation of dendritic cells and macrophages resulted in increased IL-12 secretion, which could upregulate NK cell activation. The increased secretion of IL-12, IFN-γ, and TNF-α enhanced the activity and phagocytic ability of NK cells. Thus, MCPL-7 may provide a potential therapeutic approach for both immunomodulatory and antitumor effects.

Original languageEnglish
Pages (from-to)460-466
Number of pages7
JournalJournal of Ethnopharmacology
Volume133
Issue number2
DOIs
Publication statusPublished - Jan 27 2011
Externally publishedYes

Keywords

  • Antitumor
  • Immunomodulation
  • Phellinus linteus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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