Abstract
Background/Purpose: Patients with thalassemia trait (TT) may have anemia. This study evaluated whether TT patients had specific oral manifestations and a particular blood profile compared with normal individuals. Methods: The oral manifestations and mean red blood cell count, corpuscular cell volume, red blood cell distribution width, Mentzer index, and Green and King index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin B12, folic acid, and homocysteine in 65 TT patients and in 130 age- and sex-matched healthy controls were measured and compared. Results: TT patients had significantly higher frequencies of all oral manifestations than healthy controls (p<0.001 for all), in which burning sensation of oral mucosa (90.8%), lingual varicosity (90.8%), dry mouth (72.3%), atrophic glossitis (32.3%), and numbness of the oral mucosa (30.8%) were the five leading oral manifestations for TT patients. Moreover, TT patients had significantly lower mean hemoglobin level, corpuscular cell volume, Mentzer index, and Green and King index (p<0.001 for all) as well as significantly higher mean red blood cell count and red blood cell distribution width (p<0.001 for both) than healthy controls. However, no significant difference in the mean blood iron, total iron binding capacity, vitamin B12, folic acid, or homocysteine levels was discovered between 65 TT patients and 130 healthy controls. Conclusion: TT patients have specific oral manifestations and a particular blood profile compared to normal individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 761-765 |
| Number of pages | 5 |
| Journal | Journal of the Formosan Medical Association |
| Volume | 112 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2013 |
| Externally published | Yes |
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Keywords
- Burning sensation
- Green and King index
- Hemoglobin
- Mean corpuscular volume
- Mentzer index
- Oral manifestation
ASJC Scopus subject areas
- Medicine(all)
Cite this
Oral manifestations and blood profile inpatients with thalassemia trait. / Wang, Yi Ping; Yu-Fong Chang, Julia; Wu, Yang Che; Cheng, Shih Jung; Chen, Hsin Ming; Sun, Andy.
In: Journal of the Formosan Medical Association, Vol. 112, No. 12, 01.12.2013, p. 761-765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral manifestations and blood profile inpatients with thalassemia trait
AU - Wang, Yi Ping
AU - Yu-Fong Chang, Julia
AU - Wu, Yang Che
AU - Cheng, Shih Jung
AU - Chen, Hsin Ming
AU - Sun, Andy
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Background/Purpose: Patients with thalassemia trait (TT) may have anemia. This study evaluated whether TT patients had specific oral manifestations and a particular blood profile compared with normal individuals. Methods: The oral manifestations and mean red blood cell count, corpuscular cell volume, red blood cell distribution width, Mentzer index, and Green and King index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin B12, folic acid, and homocysteine in 65 TT patients and in 130 age- and sex-matched healthy controls were measured and compared. Results: TT patients had significantly higher frequencies of all oral manifestations than healthy controls (p<0.001 for all), in which burning sensation of oral mucosa (90.8%), lingual varicosity (90.8%), dry mouth (72.3%), atrophic glossitis (32.3%), and numbness of the oral mucosa (30.8%) were the five leading oral manifestations for TT patients. Moreover, TT patients had significantly lower mean hemoglobin level, corpuscular cell volume, Mentzer index, and Green and King index (p<0.001 for all) as well as significantly higher mean red blood cell count and red blood cell distribution width (p<0.001 for both) than healthy controls. However, no significant difference in the mean blood iron, total iron binding capacity, vitamin B12, folic acid, or homocysteine levels was discovered between 65 TT patients and 130 healthy controls. Conclusion: TT patients have specific oral manifestations and a particular blood profile compared to normal individuals.
AB - Background/Purpose: Patients with thalassemia trait (TT) may have anemia. This study evaluated whether TT patients had specific oral manifestations and a particular blood profile compared with normal individuals. Methods: The oral manifestations and mean red blood cell count, corpuscular cell volume, red blood cell distribution width, Mentzer index, and Green and King index as well as blood concentrations of hemoglobin, iron, total iron binding capacity, vitamin B12, folic acid, and homocysteine in 65 TT patients and in 130 age- and sex-matched healthy controls were measured and compared. Results: TT patients had significantly higher frequencies of all oral manifestations than healthy controls (p<0.001 for all), in which burning sensation of oral mucosa (90.8%), lingual varicosity (90.8%), dry mouth (72.3%), atrophic glossitis (32.3%), and numbness of the oral mucosa (30.8%) were the five leading oral manifestations for TT patients. Moreover, TT patients had significantly lower mean hemoglobin level, corpuscular cell volume, Mentzer index, and Green and King index (p<0.001 for all) as well as significantly higher mean red blood cell count and red blood cell distribution width (p<0.001 for both) than healthy controls. However, no significant difference in the mean blood iron, total iron binding capacity, vitamin B12, folic acid, or homocysteine levels was discovered between 65 TT patients and 130 healthy controls. Conclusion: TT patients have specific oral manifestations and a particular blood profile compared to normal individuals.
KW - Burning sensation
KW - Green and King index
KW - Hemoglobin
KW - Mean corpuscular volume
KW - Mentzer index
KW - Oral manifestation
UR - http://www.scopus.com/inward/record.url?scp=84890226352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890226352&partnerID=8YFLogxK
U2 - 10.1016/j.jfma.2013.09.010
DO - 10.1016/j.jfma.2013.09.010
M3 - Article
C2 - 24139948
AN - SCOPUS:84890226352
VL - 112
SP - 761
EP - 765
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
SN - 0929-6646
IS - 12
ER -