Oral cancer theranostic application of feau bimetallic nanoparticles conjugated with MMP-1 antibody

Meng Tsan Tsai, Ying Sui Sun, Murugan Keerthi, Asit Kumar Panda, Udesh Dhawan, Yung Hsiang Chang, Chih Fang Lai, Michael Hsiao, Huey Yuan Wang, Ren Jei Chung

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Metastatic oral squamous cell carcinoma (SCC) displays a poor disease prognosis with a 5-year survival rate of 39%. Chemotherapy has emerged as the mainstream treatment against small clusters of cancer cells but poses more risks than benefits for metastatic cells due to the non-specificity and cytotoxicity. To overcome these obstacles, we conjugated antibodies specific for matrix metalloproteinase-1 (MMP-1), a prognostic biomarker of SCC, to iron–gold bimetallic nanoparticles (FeAu NPs) and explored the capability of this complex to target and limit SSC cell growth via magnetic field-induced hyperthermia. Our results showed that 4.32 ± 0.79 nm sized FeAu NPs were superparamagnetic in nature with a saturation magnetization (Ms) of 5.8 emu/g and elevated the media temperature to 45C, confirming the prospect to deliver hyperthermia. Furthermore, conjugation with MMP-1 antibodies resulted in a 3.07-fold higher uptake in HSC-3 (human tongue squamous cell carcinoma) cells as compared to L929 (fibroblast) cells, which translated to a 5-fold decrease in cell viability, confirming SCC targeting. Finally, upon magnetic stimulation, MMP-1-FeAu NPs conjugate triggered 89% HSC-3 cellular death, confirming the efficacy of antibody-conjugated nanoparticles in limiting SCC growth. The synergistic effect of biomarker-specific antibodies and magnetic nanoparticle-induced hyperthermia may open new doors towards SCC targeting for improved disease prognosis.

Original languageEnglish
Article number61
Issue number1
Publication statusPublished - Jan 2022


  • Cancer theranostic
  • Iron–gold bimetallic nanoparticles
  • Magnetic hyperthermia
  • Matrix metalloproteinase-1
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)


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