Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients

A randomized crossover study

I. Wen Wu, Kuang Hung Hsu, Chio Yin Sun, Chi Jen Tsai, Mai-Szu Wu, Chin Chan Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

Original languageEnglish
Pages (from-to)1719-1727
Number of pages9
JournalNephrology Dialysis Transplantation
Volume29
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Indican
Erythropoietin
Chronic Renal Insufficiency
Cross-Over Studies
Anemia
Hemoglobins
Antioxidants
Kidney
AST 120
Therapeutics

Keywords

  • Anemia
  • Carbonaceous adsorbents
  • Chronic kidney disease
  • Uremic toxins

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Medicine(all)

Cite this

Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients : A randomized crossover study. / Wu, I. Wen; Hsu, Kuang Hung; Sun, Chio Yin; Tsai, Chi Jen; Wu, Mai-Szu; Lee, Chin Chan.

In: Nephrology Dialysis Transplantation, Vol. 29, No. 9, 2014, p. 1719-1727.

Research output: Contribution to journalArticle

@article{c2cfb71359144ed6baf9bc264a9bde64,
title = "Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: A randomized crossover study",
abstract = "Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin",
keywords = "Anemia, Carbonaceous adsorbents, Chronic kidney disease, Uremic toxins",
author = "Wu, {I. Wen} and Hsu, {Kuang Hung} and Sun, {Chio Yin} and Tsai, {Chi Jen} and Mai-Szu Wu and Lee, {Chin Chan}",
year = "2014",
doi = "10.1093/ndt/gfu061",
language = "English",
volume = "29",
pages = "1719--1727",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients

T2 - A randomized crossover study

AU - Wu, I. Wen

AU - Hsu, Kuang Hung

AU - Sun, Chio Yin

AU - Tsai, Chi Jen

AU - Wu, Mai-Szu

AU - Lee, Chin Chan

PY - 2014

Y1 - 2014

N2 - Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

AB - Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

KW - Anemia

KW - Carbonaceous adsorbents

KW - Chronic kidney disease

KW - Uremic toxins

UR - http://www.scopus.com/inward/record.url?scp=84907417174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907417174&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfu061

DO - 10.1093/ndt/gfu061

M3 - Article

VL - 29

SP - 1719

EP - 1727

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 9

ER -