Open-lung biopsy in patients with pulmonary infiltrate.

J. B. Chen, C. Y. Chen, N. Y. Hsu, C. L. Chen, C. T. Lin, C. P. Hsu, P. Y. Wang

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Abstract

The application of open-lung biopsy to a patient with diffuse pulmonary infiltrate is dependent on whether it affords to a specific information and leads to a change in therapy. To evaluate the impact of open-lung biopsy on diagnosis and treatment of diffuse pulmonary infiltrates, we conducted a retrospective review of 37 patients undergoing this procedure during a 8-year period. There were 26 males and 11 females, at an average age of 53 years (ranging from 3 months to 79 years). Diagnostic yield was 97.2%, and biopsy yielded a specific diagnosis in 25(67.6%) patients and a change in therapy in 19 (51.4%) patients. Complications developed in 4 (11%) patients and the rate was higher under local anesthesia (3/4). Seven patients died, but no one was related to biopsy procedure. A specific diagnosis was obtained in 4 (50%) of the 8 immunocompromised patients, and a change in therapy occurred in 2 (25%) of these patients after biopsy, but these findings could not affect the survival rates. A specific diagnosis was obtained in 21 (72.4%) of the 29 nonimmunocompromised patients and a change in therapy occurred in 17 (58.6%) patients in this group. Five (83%) of 6 patients, who lacked definite tissue diagnosis by transbronchial biopsy, achieved confirmed diagnosis by open-lung biopsy. Open-lung biopsy in patients with a diffuse pulmonary infiltrate is an accurate diagnostic tool and frequently leads to a change in treatment. The procedure can be performed with acceptable morbidity and mortality in nonimmunocompromised patients, but should be used conservatively in immunocompromised patients.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalChinese Medical Journal (Taipei)
Volume48
Issue number2
Publication statusPublished - Aug 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Chen, J. B., Chen, C. Y., Hsu, N. Y., Chen, C. L., Lin, C. T., Hsu, C. P., & Wang, P. Y. (1991). Open-lung biopsy in patients with pulmonary infiltrate. Chinese Medical Journal (Taipei), 48(2), 103-109.