One-year outcomes of acute decompensated systolic heart failure in Taiwan: Lessons from TSOC-HFreF registry

Hung Yu Chang, Chun Chieh Wang, Yen Wen Wu, Pao Hsien Chu, Chih Cheng Wu, Chih Hsin Hsu, Ming Shien Wen, Wen Chol Voon, Wei Shiang Lin, Jin Long Huang, Shyh Ming Chen, Ning I. Yang, Heng Chia Chang, Kuan Cheng Chang, Shih Hsien Sung, Kou Gi Shyu, Jiunn Lee Lin, Guang Yuan Mar, Kuei Chuan Chan, Jen Yuan KuoJi Hung Wang, Zhih Cherng Chen, Wei Kung Tseng, Wen Jin Cherng, Wei Hsian Yin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Heart failure (HF) is a global health problem. The Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry was a multicenter, observational survey of patients admitted with HFrEF in Taiwan. The aim of this study was to report the one-year outcome in this large-cohort of hospitalized patients presenting with acute decompensated HFrEF. Methods: Patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan. A total of 1509 patients were enrolled into the registry by the end of October 2014. Clinical status, readmission rates and dispensed medications were collected and analyzed 1 year after patient index hospitalization. Results: Our study indicated that re-hospitalization rates after HFrEF were 31.9% and 38.5% at 6 and 12 months after index hospitalization, respectively. Of these patients, 9.7% of themwere readmittedmore than once. At 6 and 12 months after hospital discharge, all-cause mortality rates were 9.5% and 15.9%, respectively, and cardiovascular mortality rateswere 6.8% and 10.5%, respectively. Twenty-three patients (1.5%) underwent heart transplantation. During a follow-up period of 1 year, 46.4% of patients were free from mortality, HF re-hospitalization, left ventricular assist device use and heart transplantation. At the conclusion of follow-up, 57.5% of patients were prescribed either with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers; also, 66.3% were prescribed with beta-blockers and 40.8% were prescribed with mineralocorticoid receptor antagonists. Conclusions: The TSOC-HFrEF registry showed evidence of suboptimal practice of guideline-directed medical therapy and high HF re-hospitalization rate in Taiwan. The one-year mortality rate of the TSOC-HFrEF registry remained high. Ultimately, our data indicated a need for further improvement in HF care.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalActa Cardiologica Sinica
Volume33
Issue number2
DOIs
Publication statusPublished - Mar 1 2017
Externally publishedYes

Fingerprint

Systolic Heart Failure
Taiwan
Registries
Heart Failure
Hospitalization
Cardiology
Mortality
Heart Transplantation
Mineralocorticoid Receptor Antagonists
Heart-Assist Devices
Angiotensin Receptor Antagonists
Practice Guidelines
Angiotensin-Converting Enzyme Inhibitors

Keywords

  • Beta-blocker
  • Heart failure
  • Mortality
  • Renin-angiotensin blockade
  • Taiwan
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chang, H. Y., Wang, C. C., Wu, Y. W., Chu, P. H., Wu, C. C., Hsu, C. H., ... Yin, W. H. (2017). One-year outcomes of acute decompensated systolic heart failure in Taiwan: Lessons from TSOC-HFreF registry. Acta Cardiologica Sinica, 33(2), 127-138. https://doi.org/10.6515/ACS20170202A

One-year outcomes of acute decompensated systolic heart failure in Taiwan : Lessons from TSOC-HFreF registry. / Chang, Hung Yu; Wang, Chun Chieh; Wu, Yen Wen; Chu, Pao Hsien; Wu, Chih Cheng; Hsu, Chih Hsin; Wen, Ming Shien; Voon, Wen Chol; Lin, Wei Shiang; Huang, Jin Long; Chen, Shyh Ming; Yang, Ning I.; Chang, Heng Chia; Chang, Kuan Cheng; Sung, Shih Hsien; Shyu, Kou Gi; Lin, Jiunn Lee; Mar, Guang Yuan; Chan, Kuei Chuan; Kuo, Jen Yuan; Wang, Ji Hung; Chen, Zhih Cherng; Tseng, Wei Kung; Cherng, Wen Jin; Yin, Wei Hsian.

In: Acta Cardiologica Sinica, Vol. 33, No. 2, 01.03.2017, p. 127-138.

Research output: Contribution to journalArticle

Chang, HY, Wang, CC, Wu, YW, Chu, PH, Wu, CC, Hsu, CH, Wen, MS, Voon, WC, Lin, WS, Huang, JL, Chen, SM, Yang, NI, Chang, HC, Chang, KC, Sung, SH, Shyu, KG, Lin, JL, Mar, GY, Chan, KC, Kuo, JY, Wang, JH, Chen, ZC, Tseng, WK, Cherng, WJ & Yin, WH 2017, 'One-year outcomes of acute decompensated systolic heart failure in Taiwan: Lessons from TSOC-HFreF registry', Acta Cardiologica Sinica, vol. 33, no. 2, pp. 127-138. https://doi.org/10.6515/ACS20170202A
Chang, Hung Yu ; Wang, Chun Chieh ; Wu, Yen Wen ; Chu, Pao Hsien ; Wu, Chih Cheng ; Hsu, Chih Hsin ; Wen, Ming Shien ; Voon, Wen Chol ; Lin, Wei Shiang ; Huang, Jin Long ; Chen, Shyh Ming ; Yang, Ning I. ; Chang, Heng Chia ; Chang, Kuan Cheng ; Sung, Shih Hsien ; Shyu, Kou Gi ; Lin, Jiunn Lee ; Mar, Guang Yuan ; Chan, Kuei Chuan ; Kuo, Jen Yuan ; Wang, Ji Hung ; Chen, Zhih Cherng ; Tseng, Wei Kung ; Cherng, Wen Jin ; Yin, Wei Hsian. / One-year outcomes of acute decompensated systolic heart failure in Taiwan : Lessons from TSOC-HFreF registry. In: Acta Cardiologica Sinica. 2017 ; Vol. 33, No. 2. pp. 127-138.
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abstract = "Background: Heart failure (HF) is a global health problem. The Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry was a multicenter, observational survey of patients admitted with HFrEF in Taiwan. The aim of this study was to report the one-year outcome in this large-cohort of hospitalized patients presenting with acute decompensated HFrEF. Methods: Patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan. A total of 1509 patients were enrolled into the registry by the end of October 2014. Clinical status, readmission rates and dispensed medications were collected and analyzed 1 year after patient index hospitalization. Results: Our study indicated that re-hospitalization rates after HFrEF were 31.9{\%} and 38.5{\%} at 6 and 12 months after index hospitalization, respectively. Of these patients, 9.7{\%} of themwere readmittedmore than once. At 6 and 12 months after hospital discharge, all-cause mortality rates were 9.5{\%} and 15.9{\%}, respectively, and cardiovascular mortality rateswere 6.8{\%} and 10.5{\%}, respectively. Twenty-three patients (1.5{\%}) underwent heart transplantation. During a follow-up period of 1 year, 46.4{\%} of patients were free from mortality, HF re-hospitalization, left ventricular assist device use and heart transplantation. At the conclusion of follow-up, 57.5{\%} of patients were prescribed either with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers; also, 66.3{\%} were prescribed with beta-blockers and 40.8{\%} were prescribed with mineralocorticoid receptor antagonists. Conclusions: The TSOC-HFrEF registry showed evidence of suboptimal practice of guideline-directed medical therapy and high HF re-hospitalization rate in Taiwan. The one-year mortality rate of the TSOC-HFrEF registry remained high. Ultimately, our data indicated a need for further improvement in HF care.",
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author = "Chang, {Hung Yu} and Wang, {Chun Chieh} and Wu, {Yen Wen} and Chu, {Pao Hsien} and Wu, {Chih Cheng} and Hsu, {Chih Hsin} and Wen, {Ming Shien} and Voon, {Wen Chol} and Lin, {Wei Shiang} and Huang, {Jin Long} and Chen, {Shyh Ming} and Yang, {Ning I.} and Chang, {Heng Chia} and Chang, {Kuan Cheng} and Sung, {Shih Hsien} and Shyu, {Kou Gi} and Lin, {Jiunn Lee} and Mar, {Guang Yuan} and Chan, {Kuei Chuan} and Kuo, {Jen Yuan} and Wang, {Ji Hung} and Chen, {Zhih Cherng} and Tseng, {Wei Kung} and Cherng, {Wen Jin} and Yin, {Wei Hsian}",
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T1 - One-year outcomes of acute decompensated systolic heart failure in Taiwan

T2 - Lessons from TSOC-HFreF registry

AU - Chang, Hung Yu

AU - Wang, Chun Chieh

AU - Wu, Yen Wen

AU - Chu, Pao Hsien

AU - Wu, Chih Cheng

AU - Hsu, Chih Hsin

AU - Wen, Ming Shien

AU - Voon, Wen Chol

AU - Lin, Wei Shiang

AU - Huang, Jin Long

AU - Chen, Shyh Ming

AU - Yang, Ning I.

AU - Chang, Heng Chia

AU - Chang, Kuan Cheng

AU - Sung, Shih Hsien

AU - Shyu, Kou Gi

AU - Lin, Jiunn Lee

AU - Mar, Guang Yuan

AU - Chan, Kuei Chuan

AU - Kuo, Jen Yuan

AU - Wang, Ji Hung

AU - Chen, Zhih Cherng

AU - Tseng, Wei Kung

AU - Cherng, Wen Jin

AU - Yin, Wei Hsian

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: Heart failure (HF) is a global health problem. The Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry was a multicenter, observational survey of patients admitted with HFrEF in Taiwan. The aim of this study was to report the one-year outcome in this large-cohort of hospitalized patients presenting with acute decompensated HFrEF. Methods: Patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan. A total of 1509 patients were enrolled into the registry by the end of October 2014. Clinical status, readmission rates and dispensed medications were collected and analyzed 1 year after patient index hospitalization. Results: Our study indicated that re-hospitalization rates after HFrEF were 31.9% and 38.5% at 6 and 12 months after index hospitalization, respectively. Of these patients, 9.7% of themwere readmittedmore than once. At 6 and 12 months after hospital discharge, all-cause mortality rates were 9.5% and 15.9%, respectively, and cardiovascular mortality rateswere 6.8% and 10.5%, respectively. Twenty-three patients (1.5%) underwent heart transplantation. During a follow-up period of 1 year, 46.4% of patients were free from mortality, HF re-hospitalization, left ventricular assist device use and heart transplantation. At the conclusion of follow-up, 57.5% of patients were prescribed either with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers; also, 66.3% were prescribed with beta-blockers and 40.8% were prescribed with mineralocorticoid receptor antagonists. Conclusions: The TSOC-HFrEF registry showed evidence of suboptimal practice of guideline-directed medical therapy and high HF re-hospitalization rate in Taiwan. The one-year mortality rate of the TSOC-HFrEF registry remained high. Ultimately, our data indicated a need for further improvement in HF care.

AB - Background: Heart failure (HF) is a global health problem. The Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry was a multicenter, observational survey of patients admitted with HFrEF in Taiwan. The aim of this study was to report the one-year outcome in this large-cohort of hospitalized patients presenting with acute decompensated HFrEF. Methods: Patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan. A total of 1509 patients were enrolled into the registry by the end of October 2014. Clinical status, readmission rates and dispensed medications were collected and analyzed 1 year after patient index hospitalization. Results: Our study indicated that re-hospitalization rates after HFrEF were 31.9% and 38.5% at 6 and 12 months after index hospitalization, respectively. Of these patients, 9.7% of themwere readmittedmore than once. At 6 and 12 months after hospital discharge, all-cause mortality rates were 9.5% and 15.9%, respectively, and cardiovascular mortality rateswere 6.8% and 10.5%, respectively. Twenty-three patients (1.5%) underwent heart transplantation. During a follow-up period of 1 year, 46.4% of patients were free from mortality, HF re-hospitalization, left ventricular assist device use and heart transplantation. At the conclusion of follow-up, 57.5% of patients were prescribed either with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers; also, 66.3% were prescribed with beta-blockers and 40.8% were prescribed with mineralocorticoid receptor antagonists. Conclusions: The TSOC-HFrEF registry showed evidence of suboptimal practice of guideline-directed medical therapy and high HF re-hospitalization rate in Taiwan. The one-year mortality rate of the TSOC-HFrEF registry remained high. Ultimately, our data indicated a need for further improvement in HF care.

KW - Beta-blocker

KW - Heart failure

KW - Mortality

KW - Renin-angiotensin blockade

KW - Taiwan

KW - Treatment

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