One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng, Yu Wan Chu, Hsiang Ping Tsai, Chun Mao Lin, Jaulang Hwang, Yen Ho Chu

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

Original languageEnglish
Pages (from-to)920-923
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
Publication statusPublished - Mar 4 2011

    Fingerprint

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Tseng, M. C., Chu, Y. W., Tsai, H. P., Lin, C. M., Hwang, J., & Chu, Y. H. (2011). One-pot synthesis of luotonin A and its analogues. Organic Letters, 13(5), 920-923. https://doi.org/10.1021/ol1029707