One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng, Yu Wan Chu, Hsiang Ping Tsai, Chun Mao Lin, Jaulang Hwang, Yen Ho Chu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

Original languageEnglish
Pages (from-to)920-923
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
Publication statusPublished - Mar 4 2011

Fingerprint

reagents
Chemical Phenomena
analogs
Quinazolines
Type I DNA Topoisomerase
synthesis
metals
Metals
luotonin A
pyrroloquinoline

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Tseng, M. C., Chu, Y. W., Tsai, H. P., Lin, C. M., Hwang, J., & Chu, Y. H. (2011). One-pot synthesis of luotonin A and its analogues. Organic Letters, 13(5), 920-923. https://doi.org/10.1021/ol1029707

One-pot synthesis of luotonin A and its analogues. / Tseng, Ming Chung; Chu, Yu Wan; Tsai, Hsiang Ping; Lin, Chun Mao; Hwang, Jaulang; Chu, Yen Ho.

In: Organic Letters, Vol. 13, No. 5, 04.03.2011, p. 920-923.

Research output: Contribution to journalArticle

Tseng, MC, Chu, YW, Tsai, HP, Lin, CM, Hwang, J & Chu, YH 2011, 'One-pot synthesis of luotonin A and its analogues', Organic Letters, vol. 13, no. 5, pp. 920-923. https://doi.org/10.1021/ol1029707
Tseng MC, Chu YW, Tsai HP, Lin CM, Hwang J, Chu YH. One-pot synthesis of luotonin A and its analogues. Organic Letters. 2011 Mar 4;13(5):920-923. https://doi.org/10.1021/ol1029707
Tseng, Ming Chung ; Chu, Yu Wan ; Tsai, Hsiang Ping ; Lin, Chun Mao ; Hwang, Jaulang ; Chu, Yen Ho. / One-pot synthesis of luotonin A and its analogues. In: Organic Letters. 2011 ; Vol. 13, No. 5. pp. 920-923.
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