Abstract

Background: The intersphincteric resection technique has been used to extend the opportunity for sphincter preservation in patients with very low rectal cancer. The aim of this study is to assess the long-term oncological and functional outcomes of intersphincteric resection. Methods: Patients with extraperitoneal rectal cancer were treated and retrospectively chart reviewed. The oncological and functional outcomes were evaluated. Comparisons of the overall disease-free survival and recurrence were analyzed for the different surgical procedures. Results: From July 2002 to August 2009, 162 patients with extraperitoneal rectal cancer were retrospectively chart reviewed. One-hundred one patients (62.3%) underwent low anterior resection, 26 patients (16%) received radical proctectomy and intersphincteric resection with coloanal anastomosis, and 23 (14.2%) had abdominoperineal resection. The sphincter preservation rate was 80%. In the intersphincteric resection group, overall survival rates at 3 and 5 y were 83% and 83%, and disease-free survival at 3 and 5 y were 82% and 76%, respectively. The mean stool frequency was 4.7 per 24 h. There were 38.1% of patients suffering from stool fragmentation, and 23.8% had nocturnal defecation. About one-third of the patients required antidiarrheal medications. Overall, 90.8% of patients were satisfied with the functional results of surgery. Conclusions: Our data show intersphincteric resection for low rectal cancer is feasible and safe. Preoperative radiotherapy may negatively affect symptom-specific quality of life.

Original languageEnglish
Pages (from-to)e93-e98
JournalJournal of Surgical Research
Volume170
Issue number1
DOIs
Publication statusPublished - Sep 2011

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Rectal Neoplasms
Disease-Free Survival
Antidiarrheals
Defecation
Radiotherapy
Survival Rate
Quality of Life
Recurrence

Keywords

  • intersphincteric resection
  • quality of life
  • rectal cancer
  • survival

ASJC Scopus subject areas

  • Surgery

Cite this

Oncological and functional outcomes of intersphincteric resection for low rectal cancer. / Kuo, Li Jen; Hung, Chin Sheng; Wu, Chien Hua; Wang, Web; Tam, Ka Wai; Liang, Hung Hua; Chang, Yu Jia; Wei, Po Li.

In: Journal of Surgical Research, Vol. 170, No. 1, 09.2011, p. e93-e98.

Research output: Contribution to journalArticle

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abstract = "Background: The intersphincteric resection technique has been used to extend the opportunity for sphincter preservation in patients with very low rectal cancer. The aim of this study is to assess the long-term oncological and functional outcomes of intersphincteric resection. Methods: Patients with extraperitoneal rectal cancer were treated and retrospectively chart reviewed. The oncological and functional outcomes were evaluated. Comparisons of the overall disease-free survival and recurrence were analyzed for the different surgical procedures. Results: From July 2002 to August 2009, 162 patients with extraperitoneal rectal cancer were retrospectively chart reviewed. One-hundred one patients (62.3{\%}) underwent low anterior resection, 26 patients (16{\%}) received radical proctectomy and intersphincteric resection with coloanal anastomosis, and 23 (14.2{\%}) had abdominoperineal resection. The sphincter preservation rate was 80{\%}. In the intersphincteric resection group, overall survival rates at 3 and 5 y were 83{\%} and 83{\%}, and disease-free survival at 3 and 5 y were 82{\%} and 76{\%}, respectively. The mean stool frequency was 4.7 per 24 h. There were 38.1{\%} of patients suffering from stool fragmentation, and 23.8{\%} had nocturnal defecation. About one-third of the patients required antidiarrheal medications. Overall, 90.8{\%} of patients were satisfied with the functional results of surgery. Conclusions: Our data show intersphincteric resection for low rectal cancer is feasible and safe. Preoperative radiotherapy may negatively affect symptom-specific quality of life.",
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T1 - Oncological and functional outcomes of intersphincteric resection for low rectal cancer

AU - Kuo, Li Jen

AU - Hung, Chin Sheng

AU - Wu, Chien Hua

AU - Wang, Web

AU - Tam, Ka Wai

AU - Liang, Hung Hua

AU - Chang, Yu Jia

AU - Wei, Po Li

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N2 - Background: The intersphincteric resection technique has been used to extend the opportunity for sphincter preservation in patients with very low rectal cancer. The aim of this study is to assess the long-term oncological and functional outcomes of intersphincteric resection. Methods: Patients with extraperitoneal rectal cancer were treated and retrospectively chart reviewed. The oncological and functional outcomes were evaluated. Comparisons of the overall disease-free survival and recurrence were analyzed for the different surgical procedures. Results: From July 2002 to August 2009, 162 patients with extraperitoneal rectal cancer were retrospectively chart reviewed. One-hundred one patients (62.3%) underwent low anterior resection, 26 patients (16%) received radical proctectomy and intersphincteric resection with coloanal anastomosis, and 23 (14.2%) had abdominoperineal resection. The sphincter preservation rate was 80%. In the intersphincteric resection group, overall survival rates at 3 and 5 y were 83% and 83%, and disease-free survival at 3 and 5 y were 82% and 76%, respectively. The mean stool frequency was 4.7 per 24 h. There were 38.1% of patients suffering from stool fragmentation, and 23.8% had nocturnal defecation. About one-third of the patients required antidiarrheal medications. Overall, 90.8% of patients were satisfied with the functional results of surgery. Conclusions: Our data show intersphincteric resection for low rectal cancer is feasible and safe. Preoperative radiotherapy may negatively affect symptom-specific quality of life.

AB - Background: The intersphincteric resection technique has been used to extend the opportunity for sphincter preservation in patients with very low rectal cancer. The aim of this study is to assess the long-term oncological and functional outcomes of intersphincteric resection. Methods: Patients with extraperitoneal rectal cancer were treated and retrospectively chart reviewed. The oncological and functional outcomes were evaluated. Comparisons of the overall disease-free survival and recurrence were analyzed for the different surgical procedures. Results: From July 2002 to August 2009, 162 patients with extraperitoneal rectal cancer were retrospectively chart reviewed. One-hundred one patients (62.3%) underwent low anterior resection, 26 patients (16%) received radical proctectomy and intersphincteric resection with coloanal anastomosis, and 23 (14.2%) had abdominoperineal resection. The sphincter preservation rate was 80%. In the intersphincteric resection group, overall survival rates at 3 and 5 y were 83% and 83%, and disease-free survival at 3 and 5 y were 82% and 76%, respectively. The mean stool frequency was 4.7 per 24 h. There were 38.1% of patients suffering from stool fragmentation, and 23.8% had nocturnal defecation. About one-third of the patients required antidiarrheal medications. Overall, 90.8% of patients were satisfied with the functional results of surgery. Conclusions: Our data show intersphincteric resection for low rectal cancer is feasible and safe. Preoperative radiotherapy may negatively affect symptom-specific quality of life.

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