Abstract

OBJECTIVES:: Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. METHODS:: Eighteen patients with painful diabetic polyneuropathy underwent 2 consecutive 12-week periods of treatment either in the sequence of saline (control) and then BoNT/A (SB cohort, n=9) or BoNT/A followed by saline (BS cohort, n=9). Sensory perception was assessed according to the tactile threshold [TT, logarithmized force (g) of von Frey filaments] and mechanical pain threshold [PT, logarithmized weight (g) of weighted syringes], both being averages from 4 individual measurements of bilateral medial and lateral feet obtained at baseline (before injections) and at weeks 1, 4, 8, and 12 after treatment. RESULTS:: In either the SB or the BS cohort, there was a decrease in the TT and the PT after treatment with BoNT/A but not with saline. In the analysis merging both cohorts (n=18), BoNT/A resulted in a significant decrease in TT and PT at weeks 1, 4, 8, and 12 (all Ps

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalClinical Journal of Pain
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Pain Perception
Diabetic Neuropathies
Touch
Pain Threshold
Syringes
Neuralgia
onabotulinumtoxinA
Cross-Over Studies
Foot
Therapeutics
Weights and Measures
Injections

Keywords

  • Diabetes mellitus
  • Neuropathic pain
  • OnabotulinumtoxinA (BoNT/A)
  • Pain threshold
  • Quantitative sensory testing (QST)
  • Tactile threshold

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy. / Chen, Wei Ta; Yuan, Rey-Yue; Chiang, Shu Chiung; Sheu, Jau-Jiuan; Yu, Jia Ming; Tseng, Ing Jy; Yang, Szu Kuan; Chang, Hsiu Hui; Hu, Chaur-Jong.

In: Clinical Journal of Pain, Vol. 29, No. 4, 04.2013, p. 305-310.

Research output: Contribution to journalArticle

Chen, Wei Ta ; Yuan, Rey-Yue ; Chiang, Shu Chiung ; Sheu, Jau-Jiuan ; Yu, Jia Ming ; Tseng, Ing Jy ; Yang, Szu Kuan ; Chang, Hsiu Hui ; Hu, Chaur-Jong. / OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy. In: Clinical Journal of Pain. 2013 ; Vol. 29, No. 4. pp. 305-310.
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