OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy

Wei Ta Chen, Rey-Yue Yuan, Shu Chiung Chiang, Jau-Jiuan Sheu, Jia Ming Yu, Ing Jy Tseng, Szu Kuan Yang, Hsiu Hui Chang, Chaur-Jong Hu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVES:: Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. METHODS:: Eighteen patients with painful diabetic polyneuropathy underwent 2 consecutive 12-week periods of treatment either in the sequence of saline (control) and then BoNT/A (SB cohort, n=9) or BoNT/A followed by saline (BS cohort, n=9). Sensory perception was assessed according to the tactile threshold [TT, logarithmized force (g) of von Frey filaments] and mechanical pain threshold [PT, logarithmized weight (g) of weighted syringes], both being averages from 4 individual measurements of bilateral medial and lateral feet obtained at baseline (before injections) and at weeks 1, 4, 8, and 12 after treatment. RESULTS:: In either the SB or the BS cohort, there was a decrease in the TT and the PT after treatment with BoNT/A but not with saline. In the analysis merging both cohorts (n=18), BoNT/A resulted in a significant decrease in TT and PT at weeks 1, 4, 8, and 12 (all Ps

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalClinical Journal of Pain
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Keywords

  • Diabetes mellitus
  • Neuropathic pain
  • OnabotulinumtoxinA (BoNT/A)
  • Pain threshold
  • Quantitative sensory testing (QST)
  • Tactile threshold

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

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