Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome

Kok Min Seow, Yieh Loong Tsai, Chi Chang Juan, Lee Wen Huang, Jiann Loung Hwang, Low Tone Ho

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3% in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalGynecologic and Obstetric Investigation
Issue number1
Publication statusPublished - Jan 2010


  • Adipose tissue
  • Laparoscopic ovarian electrocauterization
  • Polycystic ovary syndrome
  • Receptor interacting protein 140

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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