Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome

Kok Min Seow, Yieh Loong Tsai, Chi Chang Juan, Lee Wen Huang, Jiann Loung Hwang, Low Tone Ho

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3% in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Nuclear Receptor Co-Repressor 1
Polycystic Ovary Syndrome
Fats
Messenger RNA
Ovulation
Insulin Resistance
Ovary
Fasting
Insulin
Glucose
Co-Repressor Proteins
Reverse Transcriptase Polymerase Chain Reaction
Oocytes
Adipose Tissue

Keywords

  • Adipose tissue
  • Laparoscopic ovarian electrocauterization
  • Polycystic ovary syndrome
  • Receptor interacting protein 140

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. / Seow, Kok Min; Tsai, Yieh Loong; Juan, Chi Chang; Huang, Lee Wen; Hwang, Jiann Loung; Ho, Low Tone.

In: Gynecologic and Obstetric Investigation, Vol. 69, No. 1, 01.2010, p. 51-56.

Research output: Contribution to journalArticle

Seow, Kok Min ; Tsai, Yieh Loong ; Juan, Chi Chang ; Huang, Lee Wen ; Hwang, Jiann Loung ; Ho, Low Tone. / Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome. In: Gynecologic and Obstetric Investigation. 2010 ; Vol. 69, No. 1. pp. 51-56.
@article{2b8014c151494078ba983ce2ec2069bf,
title = "Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome",
abstract = "Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3{\%} in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.",
keywords = "Adipose tissue, Laparoscopic ovarian electrocauterization, Polycystic ovary syndrome, Receptor interacting protein 140",
author = "Seow, {Kok Min} and Tsai, {Yieh Loong} and Juan, {Chi Chang} and Huang, {Lee Wen} and Hwang, {Jiann Loung} and Ho, {Low Tone}",
year = "2010",
month = "1",
doi = "10.1159/000253852",
language = "English",
volume = "69",
pages = "51--56",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome

AU - Seow, Kok Min

AU - Tsai, Yieh Loong

AU - Juan, Chi Chang

AU - Huang, Lee Wen

AU - Hwang, Jiann Loung

AU - Ho, Low Tone

PY - 2010/1

Y1 - 2010/1

N2 - Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3% in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.

AB - Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3% in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.

KW - Adipose tissue

KW - Laparoscopic ovarian electrocauterization

KW - Polycystic ovary syndrome

KW - Receptor interacting protein 140

UR - http://www.scopus.com/inward/record.url?scp=70350542695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350542695&partnerID=8YFLogxK

U2 - 10.1159/000253852

DO - 10.1159/000253852

M3 - Article

VL - 69

SP - 51

EP - 56

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 1

ER -