Abstract
Objectives: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. Method: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. Results: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 ± 16 vs. 183 ± 19 s, p = 0.001) and increased behaviors of swimming (32 ± 7 vs. 45 ± 9 s, p = 0.012) and climbing (50 ± 10 vs. 73 ± 14 s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = - 0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). Conclusion: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST.
| Original language | English |
|---|---|
| Pages (from-to) | 58-63 |
| Number of pages | 6 |
| Journal | Journal of Psychiatric Research |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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Keywords
- Depression
- Docosahexaenoic acid
- Eicosapentaenoic acid
- Forced-swimming test
- Omega-3 polyunsaturated fatty acids
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Omega-3 fatty acids on the forced-swimming test. / Huang, Shih Yi; Yang, Hui Ting; Chiu, Chih Chiang; Pariante, Carmine M.; Su, Kuan Pin.
In: Journal of Psychiatric Research, Vol. 42, No. 1, 01.2008, p. 58-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Omega-3 fatty acids on the forced-swimming test
AU - Huang, Shih Yi
AU - Yang, Hui Ting
AU - Chiu, Chih Chiang
AU - Pariante, Carmine M.
AU - Su, Kuan Pin
PY - 2008/1
Y1 - 2008/1
N2 - Objectives: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. Method: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. Results: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 ± 16 vs. 183 ± 19 s, p = 0.001) and increased behaviors of swimming (32 ± 7 vs. 45 ± 9 s, p = 0.012) and climbing (50 ± 10 vs. 73 ± 14 s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = - 0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). Conclusion: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST.
AB - Objectives: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. Method: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. Results: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 ± 16 vs. 183 ± 19 s, p = 0.001) and increased behaviors of swimming (32 ± 7 vs. 45 ± 9 s, p = 0.012) and climbing (50 ± 10 vs. 73 ± 14 s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = - 0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). Conclusion: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST.
KW - Depression
KW - Docosahexaenoic acid
KW - Eicosapentaenoic acid
KW - Forced-swimming test
KW - Omega-3 polyunsaturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=35248892522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35248892522&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2006.09.004
DO - 10.1016/j.jpsychires.2006.09.004
M3 - Article
C2 - 17070845
AN - SCOPUS:35248892522
VL - 42
SP - 58
EP - 63
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
IS - 1
ER -