TY - JOUR
T1 - Omega-3 fatty acids on the forced-swimming test
AU - Huang, Shih Yi
AU - Yang, Hui Ting
AU - Chiu, Chih Chiang
AU - Pariante, Carmine M.
AU - Su, Kuan Pin
N1 - Funding Information:
The work was supported by the grants from the China Medical University (CMU93-M-24 and CMU94-105), the Department of Health (DOH 94F044), and the National Science Council (NSC 94-2314-B-039-027 and NSC93-2320-B-039-001) in Taiwan.
PY - 2008/1
Y1 - 2008/1
N2 - Objectives: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. Method: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. Results: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 ± 16 vs. 183 ± 19 s, p = 0.001) and increased behaviors of swimming (32 ± 7 vs. 45 ± 9 s, p = 0.012) and climbing (50 ± 10 vs. 73 ± 14 s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = - 0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). Conclusion: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST.
AB - Objectives: Based on the findings of epidemiological data and recent clinical trials, omega-3 fatty acids seem to have a preventive and therapeutic effect on depression. Method: We examined the effect of omega-3 fatty acids on the forced-swimming test (FST) in two groups of Sprague-Dawley rats after a six-week treatment with two different diets. Behavioral responses were observed and recorded during the 5-min test. The fatty acid composition from the whole brain tissue and the RBC membrane of the rats were analyzed. Results: Comparing to control diet, omega-3 fatty acid diet significantly decreased the immobility time (218 ± 16 vs. 183 ± 19 s, p = 0.001) and increased behaviors of swimming (32 ± 7 vs. 45 ± 9 s, p = 0.012) and climbing (50 ± 10 vs. 73 ± 14 s, p = 0.011) during the FST. The group in omega-3 fatty acid diet had higher levels of docosahexaenoic acid (DHA, 50% increase) and alpha-linolenic acid (ALA, 63% increase) in the brain, and of eicosapentaenoic acid (EPA, 27% increase) in the peripheral RBC membrane. The level of brain DHA is negatively correlated to the immobility time (r = - 0.654, p = 0.006) and is positively correlated to the swimming time (r = 0.69, p = 0.003). Conclusion: The result shows that omega-3 fatty acids have a beneficial effect on preventing the development of depression-like behaviors in rats with the FST.
KW - Depression
KW - Docosahexaenoic acid
KW - Eicosapentaenoic acid
KW - Forced-swimming test
KW - Omega-3 polyunsaturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=35248892522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35248892522&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2006.09.004
DO - 10.1016/j.jpsychires.2006.09.004
M3 - Article
C2 - 17070845
AN - SCOPUS:35248892522
VL - 42
SP - 58
EP - 63
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
IS - 1
ER -
