Abstract

Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.

Original languageEnglish
Article number2830
JournalInternational Journal of Molecular Sciences
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 19 2018

Fingerprint

Drug delivery
delivery
Biodegradable polymers
drugs
Tissue
Pharmaceutical Preparations
Liposomes
Chitosan
Biomaterials
Permeation
Polymers
Toxicity
Genes
Acids
Posterior Eye Segment
Drug Administration Routes
Anterior Eye Segment
Drug Carriers
Biocompatible Materials
Gelatin

Keywords

  • Anterior
  • Biodegradable
  • Drug/gene delivery
  • Nanoparticles
  • Ocular
  • Polymeric
  • Posterior

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Ocular drug delivery : Role of degradable polymeric nanocarriers for ophthalmic application. / Tsai, Cheng Han; Wang, Peng Yuan; Lin, I. Chan; Huang, Hu; Liu, Guei Sheung; Tseng, Ching Li.

In: International Journal of Molecular Sciences, Vol. 19, No. 9, 2830, 19.09.2018.

Research output: Contribution to journalReview article

@article{12c685b3926e4fb294d6409ce5cf8476,
title = "Ocular drug delivery: Role of degradable polymeric nanocarriers for ophthalmic application",
abstract = "Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.",
keywords = "Anterior, Biodegradable, Drug/gene delivery, Nanoparticles, Ocular, Polymeric, Posterior",
author = "Tsai, {Cheng Han} and Wang, {Peng Yuan} and Lin, {I. Chan} and Hu Huang and Liu, {Guei Sheung} and Tseng, {Ching Li}",
year = "2018",
month = "9",
day = "19",
doi = "10.3390/ijms19092830",
language = "English",
volume = "19",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "9",

}

TY - JOUR

T1 - Ocular drug delivery

T2 - Role of degradable polymeric nanocarriers for ophthalmic application

AU - Tsai, Cheng Han

AU - Wang, Peng Yuan

AU - Lin, I. Chan

AU - Huang, Hu

AU - Liu, Guei Sheung

AU - Tseng, Ching Li

PY - 2018/9/19

Y1 - 2018/9/19

N2 - Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.

AB - Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retention/permeation and prolong drug release in ocular tissue. Biodegradable polymers have been explored as the base polymers to prepare nanocarriers for encasing existing drugs to enhance the therapeutic effect with better tissue adherence, prolonged drug action, improved bioavailability, decreased toxicity, and targeted delivery in eye. In this review, we summarized recent studies on sustained ocular drug/gene delivery and emphasized on the nanocarriers made by biodegradable polymers such as liposome, poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we discussed the bio-distribution of these nanocarriers in the ocular tissue and their therapeutic applications in various ocular diseases.

KW - Anterior

KW - Biodegradable

KW - Drug/gene delivery

KW - Nanoparticles

KW - Ocular

KW - Polymeric

KW - Posterior

UR - http://www.scopus.com/inward/record.url?scp=85053726542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053726542&partnerID=8YFLogxK

U2 - 10.3390/ijms19092830

DO - 10.3390/ijms19092830

M3 - Review article

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 9

M1 - 2830

ER -