Octreotide in the management of postoperative enterocutaneous fistulas and stress ulcer bleeding

R. J. Chen, J. F. Fang, M. F. Chen

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Abstract

We report two clinical experiences in the treatment of postoperative enterocutaneous fistula and stress ulcer bleeding with octreotide acetate (Sandostatin). In both patients, upper gastrointestinal bleeding occurred 7 days after operation, and the bleeding proved to be stress ulceration, by panendoscopic examination. Enterocutaneous fistulas also were found in both patients. One was high output (750 ml/day), and the other was low output (50 ml/day). Octreotide 50-100 μg was given subcutaneously every 8 h. After three doses of octreotide, a significant reduction in fistula output and control of the stress ulcer bleeding were noted. The fistulas closed promptly after nine doses of octreotide, but the first patient's fistula recurred 2 days later, with fluid losses of about 100-200 ml/day. This fistula closed spontaneously 1 month after discharge. Octreotide appears to be useful as an adjunct to the conventional treatment of enterocutaneous fistulas, especially those complicated by stress ulcer bleeding.

Original languageEnglish
Pages (from-to)1212-1215
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume87
Issue number9
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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