Octreotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage: A prospective, randomized, controlled trial

Hwai Jeng Lin, Kun Wang, Chin Lin Perng, Rudy Tan Chua, Chen Hsen Lee, Shou Dong Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We carried out a prospective, randomized, controlled trial over a 7-month period to assay the hemostatic effects of octreotide and heater probe thermocoagulation (HPT) in 54 patients with active peptic ulcer bleeding or nonbleeding visible vessels at the ulcer base. Nineteen patients received octreotide 100 μg bolus i.v. followed by 25 μg/h i.v. for 3 days. Twenty patients received HPT. Fifteen patients received ranitidine 100 mg i.v. every 12 h. The three groups were matched for sex, age, location of bleeders, endoscopic findings, shock, and initial hemoglobin. Ultimate hemostasis was obtained in 11 (58%) of the octreotide group, 18 (90%) of the heater probe group, and 8 (53%) of the control group (p <0.05). Volume of blood transfused, number of patients receiving operation, hospital stay, and number of deaths were not statistically significant among the three groups. We conclude that HPT is more effective than octreotide in the arrest of peptic ulcer bleeding.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume21
Issue number2
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Heater probe
  • Hemostasis
  • Octreotide
  • Rebleeding
  • Shock

ASJC Scopus subject areas

  • Gastroenterology

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