Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: A population-based matched-cohort study

Shiu Dong Chung, Ching Chun Lin, Shih Ping Liu, Herng Ching Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset. Methods: This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA. Results: Incidences of BPS/IC during the 3-year follow-up period were 13.61 (95% confidence interval [CI] = 7.37-23.13) and 3.60 (95% CI = 2.06-4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95% CI = 1.81-7.62, P <0.001) that of comparison subjects. Conclusions: This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalNeurourology and Urodynamics
Volume33
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Interstitial Cystitis
Obstructive Sleep Apnea
Urinary Bladder
Cohort Studies
Pain
Population
Confidence Intervals
Sleep
Snoring
Tobacco Use Disorder
Chronic Fatigue Syndrome
Pelvic Pain
Irritable Bowel Syndrome
Panic Disorder
Sjogren's Syndrome
Endometriosis
Hyperlipidemias
Migraine Disorders
Taiwan
Proportional Hazards Models

Keywords

  • IC/BPS
  • interstitial cystitis
  • obstructive sleep apnea

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis : A population-based matched-cohort study. / Chung, Shiu Dong; Lin, Ching Chun; Liu, Shih Ping; Lin, Herng Ching.

In: Neurourology and Urodynamics, Vol. 33, No. 3, 2014, p. 278-282.

Research output: Contribution to journalArticle

@article{286b639dab6b4941bfed5813e47fcde8,
title = "Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: A population-based matched-cohort study",
abstract = "Aims: Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset. Methods: This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA. Results: Incidences of BPS/IC during the 3-year follow-up period were 13.61 (95{\%} confidence interval [CI] = 7.37-23.13) and 3.60 (95{\%} CI = 2.06-4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95{\%} CI = 1.81-7.62, P <0.001) that of comparison subjects. Conclusions: This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population.",
keywords = "IC/BPS, interstitial cystitis, obstructive sleep apnea",
author = "Chung, {Shiu Dong} and Lin, {Ching Chun} and Liu, {Shih Ping} and Lin, {Herng Ching}",
year = "2014",
doi = "10.1002/nau.22401",
language = "English",
volume = "33",
pages = "278--282",
journal = "Neurourology and Urodynamics",
issn = "0733-2467",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis

T2 - A population-based matched-cohort study

AU - Chung, Shiu Dong

AU - Lin, Ching Chun

AU - Liu, Shih Ping

AU - Lin, Herng Ching

PY - 2014

Y1 - 2014

N2 - Aims: Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset. Methods: This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA. Results: Incidences of BPS/IC during the 3-year follow-up period were 13.61 (95% confidence interval [CI] = 7.37-23.13) and 3.60 (95% CI = 2.06-4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95% CI = 1.81-7.62, P <0.001) that of comparison subjects. Conclusions: This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population.

AB - Aims: Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset. Methods: This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA. Results: Incidences of BPS/IC during the 3-year follow-up period were 13.61 (95% confidence interval [CI] = 7.37-23.13) and 3.60 (95% CI = 2.06-4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95% CI = 1.81-7.62, P <0.001) that of comparison subjects. Conclusions: This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population.

KW - IC/BPS

KW - interstitial cystitis

KW - obstructive sleep apnea

UR - http://www.scopus.com/inward/record.url?scp=84896397164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896397164&partnerID=8YFLogxK

U2 - 10.1002/nau.22401

DO - 10.1002/nau.22401

M3 - Article

C2 - 23553652

AN - SCOPUS:84896397164

VL - 33

SP - 278

EP - 282

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

SN - 0733-2467

IS - 3

ER -