Abstract

Background: Obstructive sleep apnea (OSA) has been associated with chronic inflammation. However, no data regarding the risk for autoimmune disease in patients with OSA has been reported. This study aims to investigate the longitudinal risk for the development of certain autoimmune diseases in patients with OSA. Methods: For the study cohort, we identified 1411 patients from the Taiwan Longitudinal Health Insurance Database who had a diagnosis of OSA. For controls, 7055 subjects matched in terms of sex, age, and the index year were randomly extracted from the same database. Each patient was tracked for a five-year period to identify those patients who had received a diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis (AS), or systemic lupus erythematous (SLE). Stratified Cox proportional hazard regression was performed on the two cohorts to compute the risk of autoimmune diseases during follow-up period. Results: Of 8466 patients, 1.76% had developed autoimmune diseases during the five-year follow-up period; 2.91% and 1.53% for the study cohort and the controls, respectively. The stratified Cox proportional analysis revealed that, after eliminating individuals who died during the follow-up period and adjusting for geographic and socioeconomic factors, the hazard for developing autoimmune disease during the five-year follow-up period was 1.91 (95% CI = 1.32-2.77, p<0.001) times greater for patients with OSA than for controls. Conclusion: Patients with OSA have a higher risk of developing certain autoimmune diseases. Further study is advised to confirm our findings and explore the underlying pathomechanism.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalSleep Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Obstructive Sleep Apnea
Autoimmune Diseases
Population
Cohort Studies
Databases
Geography
Ankylosing Spondylitis
Health Insurance
Taiwan
Rheumatoid Arthritis
Inflammation

Keywords

  • Ankylosing spondylitis
  • Autoimmune disease
  • Inflammation
  • Obstructive sleep apnea
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Obstructive sleep apnea and the risk of autoimmune diseases: A longitudinal population-based study",
abstract = "Background: Obstructive sleep apnea (OSA) has been associated with chronic inflammation. However, no data regarding the risk for autoimmune disease in patients with OSA has been reported. This study aims to investigate the longitudinal risk for the development of certain autoimmune diseases in patients with OSA. Methods: For the study cohort, we identified 1411 patients from the Taiwan Longitudinal Health Insurance Database who had a diagnosis of OSA. For controls, 7055 subjects matched in terms of sex, age, and the index year were randomly extracted from the same database. Each patient was tracked for a five-year period to identify those patients who had received a diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis (AS), or systemic lupus erythematous (SLE). Stratified Cox proportional hazard regression was performed on the two cohorts to compute the risk of autoimmune diseases during follow-up period. Results: Of 8466 patients, 1.76{\%} had developed autoimmune diseases during the five-year follow-up period; 2.91{\%} and 1.53{\%} for the study cohort and the controls, respectively. The stratified Cox proportional analysis revealed that, after eliminating individuals who died during the follow-up period and adjusting for geographic and socioeconomic factors, the hazard for developing autoimmune disease during the five-year follow-up period was 1.91 (95{\%} CI = 1.32-2.77, p<0.001) times greater for patients with OSA than for controls. Conclusion: Patients with OSA have a higher risk of developing certain autoimmune diseases. Further study is advised to confirm our findings and explore the underlying pathomechanism.",
keywords = "Ankylosing spondylitis, Autoimmune disease, Inflammation, Obstructive sleep apnea, Rheumatoid arthritis, Systemic lupus erythematosus",
author = "Kang, {Jiunn Horng} and Lin, {Herng Ching}",
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month = "6",
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language = "English",
volume = "13",
pages = "583--588",
journal = "Sleep Medicine",
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T1 - Obstructive sleep apnea and the risk of autoimmune diseases

T2 - A longitudinal population-based study

AU - Kang, Jiunn Horng

AU - Lin, Herng Ching

PY - 2012/6

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N2 - Background: Obstructive sleep apnea (OSA) has been associated with chronic inflammation. However, no data regarding the risk for autoimmune disease in patients with OSA has been reported. This study aims to investigate the longitudinal risk for the development of certain autoimmune diseases in patients with OSA. Methods: For the study cohort, we identified 1411 patients from the Taiwan Longitudinal Health Insurance Database who had a diagnosis of OSA. For controls, 7055 subjects matched in terms of sex, age, and the index year were randomly extracted from the same database. Each patient was tracked for a five-year period to identify those patients who had received a diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis (AS), or systemic lupus erythematous (SLE). Stratified Cox proportional hazard regression was performed on the two cohorts to compute the risk of autoimmune diseases during follow-up period. Results: Of 8466 patients, 1.76% had developed autoimmune diseases during the five-year follow-up period; 2.91% and 1.53% for the study cohort and the controls, respectively. The stratified Cox proportional analysis revealed that, after eliminating individuals who died during the follow-up period and adjusting for geographic and socioeconomic factors, the hazard for developing autoimmune disease during the five-year follow-up period was 1.91 (95% CI = 1.32-2.77, p<0.001) times greater for patients with OSA than for controls. Conclusion: Patients with OSA have a higher risk of developing certain autoimmune diseases. Further study is advised to confirm our findings and explore the underlying pathomechanism.

AB - Background: Obstructive sleep apnea (OSA) has been associated with chronic inflammation. However, no data regarding the risk for autoimmune disease in patients with OSA has been reported. This study aims to investigate the longitudinal risk for the development of certain autoimmune diseases in patients with OSA. Methods: For the study cohort, we identified 1411 patients from the Taiwan Longitudinal Health Insurance Database who had a diagnosis of OSA. For controls, 7055 subjects matched in terms of sex, age, and the index year were randomly extracted from the same database. Each patient was tracked for a five-year period to identify those patients who had received a diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis (AS), or systemic lupus erythematous (SLE). Stratified Cox proportional hazard regression was performed on the two cohorts to compute the risk of autoimmune diseases during follow-up period. Results: Of 8466 patients, 1.76% had developed autoimmune diseases during the five-year follow-up period; 2.91% and 1.53% for the study cohort and the controls, respectively. The stratified Cox proportional analysis revealed that, after eliminating individuals who died during the follow-up period and adjusting for geographic and socioeconomic factors, the hazard for developing autoimmune disease during the five-year follow-up period was 1.91 (95% CI = 1.32-2.77, p<0.001) times greater for patients with OSA than for controls. Conclusion: Patients with OSA have a higher risk of developing certain autoimmune diseases. Further study is advised to confirm our findings and explore the underlying pathomechanism.

KW - Ankylosing spondylitis

KW - Autoimmune disease

KW - Inflammation

KW - Obstructive sleep apnea

KW - Rheumatoid arthritis

KW - Systemic lupus erythematosus

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