Obstruction of venous drainage linked to transient global amnesia

Ke Han, A. Ching Chao, Feng Chi Chang, Chih Ping Chung, Hung Yi Hsu, Wen Yung Sheng, Jiang Wu, Han Hwa Hu

Research output: Contribution to journalArticle

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Abstract

Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission of the intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through the vertebral venous system, and patency of internal jugular vein (IJV) is essential for venous drainage and pressure releasing. We hypothesize that obstruction of IJV venous drainage is a contributing factor in TGA pathogenesis. A magnetic resonance (MR) imaging protocol was used in 45 TGA patients and 45 age- and sex-matched controls to assess the morphologies of IJV, brachiocephalic vein (BCV) and asymmetry of transverse sinus (TS). The IJV was divided into the upper- and middle-IJV segments. Compared to the controls, TGA patients had significantly higher rates of moderate and severe compression/stenosis at the bilateral upper-IJV segment (left: 37.8% vs. 17.8%, P = 0.0393; right: 57.8% vs. 15.6%, P<0.0012), in left BCV (60% vs. 8.9%, P<0.0004), and in TS hypoplasia (53.3%% vs. 31.1%, P = 0.0405). The prevalence of at least one site of venous compression/stenosis in IJV or BCV was significantly higher in patients than in controls (91.1% vs. 33.3%, P<0.0004). The diameter of the left TS in MRV, but not in T1 contrast imaging, was significantly smaller in TGA patients than in controls (0.31±0.21 vs. 0.41±0.19, P = 0.0290), which was compatible with downstream venous stenosis/obstruction. TGA patients have a higher prevalence of compression/stenosis of the bilateral IJV and the left BCV and TS hypoplasia, which is new evidence that supports the role of extracranial veins in TGA pathogenesis.

Original languageEnglish
Article numbere0132893
JournalPLoS One
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 14 2015

Fingerprint

Transient Global Amnesia
Jugular Veins
jugular vein
Drainage
drainage
Brachiocephalic Veins
Transverse Sinuses
sinuses
Pathologic Constriction
pathogenesis
Imaging techniques
Valsalva Maneuver
Magnetic resonance
Venous Pressure
magnetic resonance imaging
etiology
Veins
Magnetic Resonance Imaging
image analysis
Pressure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Han, K., Chao, A. C., Chang, F. C., Chung, C. P., Hsu, H. Y., Sheng, W. Y., ... Hu, H. H. (2015). Obstruction of venous drainage linked to transient global amnesia. PLoS One, 10(7), [e0132893]. https://doi.org/10.1371/journal.pone.0132893

Obstruction of venous drainage linked to transient global amnesia. / Han, Ke; Chao, A. Ching; Chang, Feng Chi; Chung, Chih Ping; Hsu, Hung Yi; Sheng, Wen Yung; Wu, Jiang; Hu, Han Hwa.

In: PLoS One, Vol. 10, No. 7, e0132893, 14.07.2015.

Research output: Contribution to journalArticle

Han, K, Chao, AC, Chang, FC, Chung, CP, Hsu, HY, Sheng, WY, Wu, J & Hu, HH 2015, 'Obstruction of venous drainage linked to transient global amnesia', PLoS One, vol. 10, no. 7, e0132893. https://doi.org/10.1371/journal.pone.0132893
Han K, Chao AC, Chang FC, Chung CP, Hsu HY, Sheng WY et al. Obstruction of venous drainage linked to transient global amnesia. PLoS One. 2015 Jul 14;10(7). e0132893. https://doi.org/10.1371/journal.pone.0132893
Han, Ke ; Chao, A. Ching ; Chang, Feng Chi ; Chung, Chih Ping ; Hsu, Hung Yi ; Sheng, Wen Yung ; Wu, Jiang ; Hu, Han Hwa. / Obstruction of venous drainage linked to transient global amnesia. In: PLoS One. 2015 ; Vol. 10, No. 7.
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