Obesity, hyperhomocysteinaemia and risk of chronic kidney disease

A population-based study

Shih Han Lai, Yi Wen Tsai, Yi Chuan Chen, Shy Shin Chang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD. Objectives. We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population. Methods. This was a retrospective cross-sectional study involving 24 826 subjects who underwent a health check-up from January 2013 to December 2015. A multivariate linear regression model was developed to analyse the relationship among BMI, serum homocysteine and estimated glomerular filtration rate (eGFR). A multivariate logistic regression model was used to assess the relationship among weight categories, hyperhomocysteinaemia and CKD. Results. The prevalence of CKD in the quartile groups of homocysteine were 2.5%, 2.7%, 3.4% and 5.2% (P < 0.01). For every one-unit increase in BMI (kg/m2), the eGFR decreased by 0.50 ml/ min/1.73 m2. Overweight/obese subjects with high homocysteine levels had a higher odds ratio (OR) for CKD, as compared with normal weight subjects (1.84 versus 1.38, respectively; P < 0.01 versus P = 0.02, respectively). Overweight/obese female subjects with hyperhomocysteinaemia had an OR of 3.40 [P < 0.01; 95% confidence interval (CI): 2.06-5.61] for CKD; in males, the OR was 1.66 (P < 0.01; 95% CI: 1.38-1.99). Conclusions. Patients who are overweight/obese with higher homocysteine levels have an increased risk of CKD, especially females. Additional studies exploring whether the effect of weight loss or homocysteine-lowering therapies such as folic acid, vitamin B12 supplements that may prevent or slow the progression of declining renal function, is warranted.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalFamily Practice
Volume35
Issue number3
DOIs
Publication statusPublished - May 23 2018

Fingerprint

Hyperhomocysteinemia
Chronic Renal Insufficiency
Homocysteine
Obesity
Population
Body Mass Index
Odds Ratio
Glomerular Filtration Rate
Linear Models
Logistic Models
Confidence Intervals
Kidney
Weights and Measures
Vitamin B 12
Folic Acid
Weight Loss
Oxidative Stress
Cardiovascular Diseases
Cross-Sectional Studies
Health

Keywords

  • Body mass index
  • Chronic
  • Glomerular filtration rate
  • Homocysteine
  • Inflammation
  • Obesity
  • Renal insufficiency

ASJC Scopus subject areas

  • Family Practice

Cite this

Obesity, hyperhomocysteinaemia and risk of chronic kidney disease : A population-based study. / Lai, Shih Han; Tsai, Yi Wen; Chen, Yi Chuan; Chang, Shy Shin.

In: Family Practice, Vol. 35, No. 3, 23.05.2018, p. 259-265.

Research output: Contribution to journalArticle

Lai, Shih Han ; Tsai, Yi Wen ; Chen, Yi Chuan ; Chang, Shy Shin. / Obesity, hyperhomocysteinaemia and risk of chronic kidney disease : A population-based study. In: Family Practice. 2018 ; Vol. 35, No. 3. pp. 259-265.
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abstract = "Background. Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD. Objectives. We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population. Methods. This was a retrospective cross-sectional study involving 24 826 subjects who underwent a health check-up from January 2013 to December 2015. A multivariate linear regression model was developed to analyse the relationship among BMI, serum homocysteine and estimated glomerular filtration rate (eGFR). A multivariate logistic regression model was used to assess the relationship among weight categories, hyperhomocysteinaemia and CKD. Results. The prevalence of CKD in the quartile groups of homocysteine were 2.5{\%}, 2.7{\%}, 3.4{\%} and 5.2{\%} (P < 0.01). For every one-unit increase in BMI (kg/m2), the eGFR decreased by 0.50 ml/ min/1.73 m2. Overweight/obese subjects with high homocysteine levels had a higher odds ratio (OR) for CKD, as compared with normal weight subjects (1.84 versus 1.38, respectively; P < 0.01 versus P = 0.02, respectively). Overweight/obese female subjects with hyperhomocysteinaemia had an OR of 3.40 [P < 0.01; 95{\%} confidence interval (CI): 2.06-5.61] for CKD; in males, the OR was 1.66 (P < 0.01; 95{\%} CI: 1.38-1.99). Conclusions. Patients who are overweight/obese with higher homocysteine levels have an increased risk of CKD, especially females. Additional studies exploring whether the effect of weight loss or homocysteine-lowering therapies such as folic acid, vitamin B12 supplements that may prevent or slow the progression of declining renal function, is warranted.",
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N2 - Background. Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD. Objectives. We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population. Methods. This was a retrospective cross-sectional study involving 24 826 subjects who underwent a health check-up from January 2013 to December 2015. A multivariate linear regression model was developed to analyse the relationship among BMI, serum homocysteine and estimated glomerular filtration rate (eGFR). A multivariate logistic regression model was used to assess the relationship among weight categories, hyperhomocysteinaemia and CKD. Results. The prevalence of CKD in the quartile groups of homocysteine were 2.5%, 2.7%, 3.4% and 5.2% (P < 0.01). For every one-unit increase in BMI (kg/m2), the eGFR decreased by 0.50 ml/ min/1.73 m2. Overweight/obese subjects with high homocysteine levels had a higher odds ratio (OR) for CKD, as compared with normal weight subjects (1.84 versus 1.38, respectively; P < 0.01 versus P = 0.02, respectively). Overweight/obese female subjects with hyperhomocysteinaemia had an OR of 3.40 [P < 0.01; 95% confidence interval (CI): 2.06-5.61] for CKD; in males, the OR was 1.66 (P < 0.01; 95% CI: 1.38-1.99). Conclusions. Patients who are overweight/obese with higher homocysteine levels have an increased risk of CKD, especially females. Additional studies exploring whether the effect of weight loss or homocysteine-lowering therapies such as folic acid, vitamin B12 supplements that may prevent or slow the progression of declining renal function, is warranted.

AB - Background. Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD. Objectives. We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population. Methods. This was a retrospective cross-sectional study involving 24 826 subjects who underwent a health check-up from January 2013 to December 2015. A multivariate linear regression model was developed to analyse the relationship among BMI, serum homocysteine and estimated glomerular filtration rate (eGFR). A multivariate logistic regression model was used to assess the relationship among weight categories, hyperhomocysteinaemia and CKD. Results. The prevalence of CKD in the quartile groups of homocysteine were 2.5%, 2.7%, 3.4% and 5.2% (P < 0.01). For every one-unit increase in BMI (kg/m2), the eGFR decreased by 0.50 ml/ min/1.73 m2. Overweight/obese subjects with high homocysteine levels had a higher odds ratio (OR) for CKD, as compared with normal weight subjects (1.84 versus 1.38, respectively; P < 0.01 versus P = 0.02, respectively). Overweight/obese female subjects with hyperhomocysteinaemia had an OR of 3.40 [P < 0.01; 95% confidence interval (CI): 2.06-5.61] for CKD; in males, the OR was 1.66 (P < 0.01; 95% CI: 1.38-1.99). Conclusions. Patients who are overweight/obese with higher homocysteine levels have an increased risk of CKD, especially females. Additional studies exploring whether the effect of weight loss or homocysteine-lowering therapies such as folic acid, vitamin B12 supplements that may prevent or slow the progression of declining renal function, is warranted.

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KW - Glomerular filtration rate

KW - Homocysteine

KW - Inflammation

KW - Obesity

KW - Renal insufficiency

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