Abstract
Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.
| Original language | English |
|---|---|
| Pages (from-to) | 300-306 |
| Number of pages | 7 |
| Journal | Gynecological Endocrinology |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2011 |
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Keywords
- insulin resistance
- obesity
- phenotypes
- Polycystic ovary syndrome
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Obstetrics and Gynaecology
Cite this
Obesity and insulin resistance in women with polycystic ovary syndrome. / Chun-Sen, Hsu; Chien-Hua, Wu; Wan-Chun, Chiu; Ching-Tzu, Lee; Chun-Jen, Chang; Ming-I, Hsu.
In: Gynecological Endocrinology, Vol. 27, No. 5, 05.2011, p. 300-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity and insulin resistance in women with polycystic ovary syndrome
AU - Chun-Sen, Hsu
AU - Chien-Hua, Wu
AU - Wan-Chun, Chiu
AU - Ching-Tzu, Lee
AU - Chun-Jen, Chang
AU - Ming-I, Hsu
PY - 2011/5
Y1 - 2011/5
N2 - Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.
AB - Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.
KW - insulin resistance
KW - obesity
KW - phenotypes
KW - Polycystic ovary syndrome
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UR - http://www.scopus.com/inward/citedby.url?scp=79953808748&partnerID=8YFLogxK
U2 - 10.3109/09513590.2010.488776
DO - 10.3109/09513590.2010.488776
M3 - Article
C2 - 20500115
AN - SCOPUS:79953808748
VL - 27
SP - 300
EP - 306
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
SN - 0951-3590
IS - 5
ER -