Abstract

Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.

Original languageEnglish
Article number9031
Pages (from-to)66-71
Number of pages6
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume192
DOIs
Publication statusPublished - Sep 1 2015

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Sex Hormone-Binding Globulin
Polycystic Ovary Syndrome
Obesity
Biomarkers
Hormones
Insulin Resistance
Interleukin-6
Resistin
Ghrelin
Adipokines
Adiponectin
Leptin
Serum
C-Reactive Protein
LDL Cholesterol
Fasting
Homeostasis
Retrospective Studies
Clinical Trials
Insulin

Keywords

  • Adiponectin
  • Inflammation
  • Leptin
  • Obesity
  • PCOS
  • Resistin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. / Shen, Szu Hung; Shen, Szu Yu; Liou, Tsan Hon; Hsu, Ming I.; Chang, Yuan Chin Ivan; Cheng, Chih Yu; Hsu, Chun-Sen; Tzeng, Chii Ruey.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 192, 9031, 01.09.2015, p. 66-71.

Research output: Contribution to journalArticle

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abstract = "Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-m{\"u}llerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.",
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author = "Shen, {Szu Hung} and Shen, {Szu Yu} and Liou, {Tsan Hon} and Hsu, {Ming I.} and Chang, {Yuan Chin Ivan} and Cheng, {Chih Yu} and Chun-Sen Hsu and Tzeng, {Chii Ruey}",
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AU - Shen, Szu Hung

AU - Shen, Szu Yu

AU - Liou, Tsan Hon

AU - Hsu, Ming I.

AU - Chang, Yuan Chin Ivan

AU - Cheng, Chih Yu

AU - Hsu, Chun-Sen

AU - Tzeng, Chii Ruey

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N2 - Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.

AB - Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.

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