Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas

Sung Hsin Kuo, Li Tzong Chen, Kun Huei Yeh, Ming Shiang Wu, Hui Chen Hsu, Pei Yen Yeh, Tsui Lien Mao, Chi Long Chen, Shin Lian Doong, Jaw Town Lin, Ann Lii Cheng

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61 Citations (Scopus)

Abstract

Purpose: A high percentage of early-stage, high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori dependent. t(11;18)(q21;q21), a genetic aberration highly predictive of H pylori-independent status in low-grade gastric MALT lymphoma, is rarely detected in its high-grade counterpart. This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-κB) is useful in predicting H pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas. Patients and Methods: Twenty-two patients who had participated in a prospective study of H pylori eradication for stage IE high-grade gastric MALT lymphomas were studied. The expression of BCL10 and NF-κB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy. The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript. Results: Aberrant nuclear expression of BCL10 was detected in seven (87.5%) of eight H pylori-independent and in none of 14 H pylori-dependent high-grade gastric MALT lymphomas (P <.001). All seven patients with nuclear BCL10 expression had nuclear expression of NF-κB, compared with only two of 15 patients without nuclear BCL10 expression (P = .002). As a single variable, the frequency of nuclear expression of NF-κB was also significantly higher in H pylori-independent tumors than in H pylori-dependent tumors (seven of eight [87.5%] v two of 15 [12.3%]; P = .002). The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H pylori-independent lymphomas. Conclusion: Nuclear expression of BCL10 or NF-κB is highly predictive of H pylori-independent status in high-grade gastric MALT lymphoma, and coexpression of these two markers in the nuclei is frequent.

Original languageEnglish
Pages (from-to)3491-3497
Number of pages7
JournalJournal of Clinical Oncology
Volume22
Issue number17
DOIs
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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