Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 )

Kun Huei Yeh, Sung Hsin Kuo, Li Tzong Chen, Tsui Lien Mao, Shin Lian Doong, Ming Shiang Wu, Hui Chen Hsu, Yi Shin Tzeng, Chi Long Chen, Jaw Town Lin, Ann Lii Cheng

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Abstract

The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent-status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-κB) was recently found to be closely associated with Hpylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P <.001). Nuclear expression of NF-κB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P <.001). Further, nuclear translocation of BCL10 and NF-κB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-κB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).

Original languageEnglish
Pages (from-to)1037-1041
Number of pages5
JournalBlood
Volume106
Issue number3
DOIs
Publication statusPublished - Aug 1 2005

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Marginal Zone B-Cell Lymphoma
NF-kappa B
Pylorus
Gastric Mucosa
Helicobacter pylori
Tissue
Tumors
Mucous Membrane
Neoplasms

ASJC Scopus subject areas

  • Hematology

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Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 ). / Yeh, Kun Huei; Kuo, Sung Hsin; Chen, Li Tzong; Mao, Tsui Lien; Doong, Shin Lian; Wu, Ming Shiang; Hsu, Hui Chen; Tzeng, Yi Shin; Chen, Chi Long; Lin, Jaw Town; Cheng, Ann Lii.

In: Blood, Vol. 106, No. 3, 01.08.2005, p. 1037-1041.

Research output: Contribution to journalArticle

Yeh, Kun Huei ; Kuo, Sung Hsin ; Chen, Li Tzong ; Mao, Tsui Lien ; Doong, Shin Lian ; Wu, Ming Shiang ; Hsu, Hui Chen ; Tzeng, Yi Shin ; Chen, Chi Long ; Lin, Jaw Town ; Cheng, Ann Lii. / Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 ). In: Blood. 2005 ; Vol. 106, No. 3. pp. 1037-1041.
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title = "Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 )",
abstract = "The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent-status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-κB) was recently found to be closely associated with Hpylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3{\%}) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6{\%}) were H pylori dependent and 11 (23.4{\%}) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7{\%}] vs 3 of 36 [8.3{\%}]; P <.001). Nuclear expression of NF-κB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6{\%}] vs 3 of 36 [8.3{\%}]; P <.001). Further, nuclear translocation of BCL10 and NF-κB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-κB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).",
author = "Yeh, {Kun Huei} and Kuo, {Sung Hsin} and Chen, {Li Tzong} and Mao, {Tsui Lien} and Doong, {Shin Lian} and Wu, {Ming Shiang} and Hsu, {Hui Chen} and Tzeng, {Yi Shin} and Chen, {Chi Long} and Lin, {Jaw Town} and Cheng, {Ann Lii}",
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T1 - Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 )

AU - Yeh, Kun Huei

AU - Kuo, Sung Hsin

AU - Chen, Li Tzong

AU - Mao, Tsui Lien

AU - Doong, Shin Lian

AU - Wu, Ming Shiang

AU - Hsu, Hui Chen

AU - Tzeng, Yi Shin

AU - Chen, Chi Long

AU - Lin, Jaw Town

AU - Cheng, Ann Lii

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent-status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-κB) was recently found to be closely associated with Hpylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P <.001). Nuclear expression of NF-κB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P <.001). Further, nuclear translocation of BCL10 and NF-κB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-κB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).

AB - The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent-status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-κB) was recently found to be closely associated with Hpylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P <.001). Nuclear expression of NF-κB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P <.001). Further, nuclear translocation of BCL10 and NF-κB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-κB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).

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