N6-(Δ2-isopentenyl)adenosine: The regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes

Robert C. Gallo, Sidney M. Hecht, Jacqueline Whang-Peng, Susan O'Hopp

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have studied the effects of N6-(Δ2-isopentenyl)adenosine and related cytokinin analogs on the stimulation and inhibition of phytohemagglutinin-induced growth of human lymphocytes. We have found that N6-(Δ2-isopentenyl)adenosine exerts inhibitory effects on RNA synthesis, uridine transport and uridylate kinase synthesis. On the basis of the interaction of N6-(Δ2-isopentenyl)adenosine with cyclic AMP in this system, we propose that the observed stimulatory and inhibitory effects may be due to the involvement of N6-(Δ2-isopentenyl)adenosine in cyclic AMP metabolism.

Original languageEnglish
Pages (from-to)488-500
Number of pages13
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume281
Issue number4
DOIs
Publication statusPublished - Nov 9 1972
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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