Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat

Chih Hao Yang, Chiung Chun Huang, Kuei Sen Hsu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Acute behavioural stress has been recognized as a strong influence on the inducibility of hippocampal long-term synaptic plasticity. We have reported previously that in adult male rats, acute behavioural stress impairs long-term potentiation (LTP) but enhances long-term depression (LTD) in the hippocampal CA1 region. In this study we report that the effects of stress on LTP and LTD were reversed when animals were introduced into a novel 'stimulus-rich' environment immediately after the stress. Novelty exploration-induced reversal of stress effects was prevented when the animals were given the NMDA receptor antagonist d-(-)-2-amino-5-phosphonopentanoic acid, the cholinergic antagonist atropine and the protein phosphatase (PP) 2B inhibitors cyclosporin A and cypermethrin, but not the α1-adrenergic antagonist prazosin, the β-adrenergic antagonist propranolol or the PP1/2A inhibitor okadaic acid, respectively before being subjected to the novel environment. In addition, the ability of novelty exploration to reverse the stress effects was mimicked by a direct application of the cholinergic agonist carbachol. Exposure to the novel environment following stress was accompanied by the activation of both PP2B and striatal-enriched tyrosine phosphatase (STEP). Taken together, these findings suggest that the activation of the cholinergic system and, in turn, the triggering of an NMDA receptor-mediated activation of PP2B to increase STEP activity appear to mediate the novelty exploration-induced reversal of stress-related modulation of hippocampal long-term synaptic plasticity.

Original languageEnglish
Pages (from-to)601-615
Number of pages15
JournalJournal of Physiology
Volume577
Issue number2
DOIs
Publication statusPublished - Dec 1 2006
Externally publishedYes

Fingerprint

Neuronal Plasticity
Corpus Striatum
Adrenergic Antagonists
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Phosphoric Monoester Hydrolases
Tyrosine
2-Amino-5-phosphonovalerate
Hippocampal CA1 Region
Cholinergic Agonists
Okadaic Acid
Prazosin
Cholinergic Antagonists
Carbachol
Atropine
Propranolol
Cholinergic Agents
Cyclosporine

ASJC Scopus subject areas

  • Physiology

Cite this

Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat. / Yang, Chih Hao; Huang, Chiung Chun; Hsu, Kuei Sen.

In: Journal of Physiology, Vol. 577, No. 2, 01.12.2006, p. 601-615.

Research output: Contribution to journalArticle

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