Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Tran Duong Thuy, Nam Nhut Phan, Chih Yang Wang, Han Gang Yu, Shu Yin Wang, Pung Ling Huang, Yi Yin Do, Yen Chang Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse benefcial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and signifcantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The fndings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.

Original languageEnglish
Pages (from-to)2949-2956
Number of pages8
JournalMolecular Medicine Reports
Volume15
Issue number5
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

Fingerprint

Therapeutic Uses
Medical problems
Experimental Diabetes Mellitus
Cardiomegaly
Bioinformatics
Streptozocin
Computational Biology
Rats
Body Weight
Rat control
Sesamum
Blood pressure
sesamin
Type 1 Diabetes Mellitus
Hypoglycemia
Oral Administration
Blood Glucose
Genes
Heart Rate
Cholesterol

Keywords

  • Cardiac dysfunction
  • Diabetes
  • Sesamin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

Cite this

Thuy, T. D., Phan, N. N., Wang, C. Y., Yu, H. G., Wang, S. Y., Huang, P. L., ... Lin, Y. C. (2017). Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports, 15(5), 2949-2956. https://doi.org/10.3892/mmr.2017.6420

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. / Thuy, Tran Duong; Phan, Nam Nhut; Wang, Chih Yang; Yu, Han Gang; Wang, Shu Yin; Huang, Pung Ling; Do, Yi Yin; Lin, Yen Chang.

In: Molecular Medicine Reports, Vol. 15, No. 5, 01.01.2017, p. 2949-2956.

Research output: Contribution to journalArticle

Thuy, TD, Phan, NN, Wang, CY, Yu, HG, Wang, SY, Huang, PL, Do, YY & Lin, YC 2017, 'Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction', Molecular Medicine Reports, vol. 15, no. 5, pp. 2949-2956. https://doi.org/10.3892/mmr.2017.6420
Thuy, Tran Duong ; Phan, Nam Nhut ; Wang, Chih Yang ; Yu, Han Gang ; Wang, Shu Yin ; Huang, Pung Ling ; Do, Yi Yin ; Lin, Yen Chang. / Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. In: Molecular Medicine Reports. 2017 ; Vol. 15, No. 5. pp. 2949-2956.
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