Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Tran Duong Thuy, Nam Nhut Phan, Chih Yang Wang, Han Gang Yu, Shu Yin Wang, Pung Ling Huang, Yi Yin Do, Yen Chang Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse benefcial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and signifcantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The fndings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.

Original languageEnglish
Pages (from-to)2949-2956
Number of pages8
JournalMolecular Medicine Reports
Volume15
Issue number5
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

Keywords

  • Cardiac dysfunction
  • Diabetes
  • Sesamin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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  • Cite this

    Thuy, T. D., Phan, N. N., Wang, C. Y., Yu, H. G., Wang, S. Y., Huang, P. L., Do, Y. Y., & Lin, Y. C. (2017). Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports, 15(5), 2949-2956. https://doi.org/10.3892/mmr.2017.6420