Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.

Original languageEnglish
Pages (from-to)1901-1907
Number of pages7
JournalChemistry and Biodiversity
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Cupressaceae
KB Cells
Diterpenes
Terpenes
Bioactivity
Skeleton
Human Activities
Squamous Cell Carcinoma

Keywords

  • Calocedrus macrolepis var. formosana
  • Calocetriol
  • Cytotoxic activity
  • Diacetylcalocetriol
  • Diterpenoids
  • Ferrugimenthenol
  • Meroterpenoids
  • Secoabietanes

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Molecular Biology
  • Molecular Medicine

Cite this

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Li, Z-H., & Kuo, Y. H. (2011). Novel terpenoids from Calocedrus macrolepis var. formosana. Chemistry and Biodiversity, 8(10), 1901-1907. https://doi.org/10.1002/cbdv.201000237

Novel terpenoids from Calocedrus macrolepis var. formosana. / Hsieh, Chin Lin; Tseng, Mei Hwei; Pan, Ryh Nan; Chang, Jang Yang; Kuo, Ching Chuan; Li, Zong-Huei; Kuo, Yueh Hsiung.

In: Chemistry and Biodiversity, Vol. 8, No. 10, 10.2011, p. 1901-1907.

Research output: Contribution to journalArticle

Hsieh, CL, Tseng, MH, Pan, RN, Chang, JY, Kuo, CC, Li, Z-H & Kuo, YH 2011, 'Novel terpenoids from Calocedrus macrolepis var. formosana', Chemistry and Biodiversity, vol. 8, no. 10, pp. 1901-1907. https://doi.org/10.1002/cbdv.201000237
Hsieh CL, Tseng MH, Pan RN, Chang JY, Kuo CC, Li Z-H et al. Novel terpenoids from Calocedrus macrolepis var. formosana. Chemistry and Biodiversity. 2011 Oct;8(10):1901-1907. https://doi.org/10.1002/cbdv.201000237
Hsieh, Chin Lin ; Tseng, Mei Hwei ; Pan, Ryh Nan ; Chang, Jang Yang ; Kuo, Ching Chuan ; Li, Zong-Huei ; Kuo, Yueh Hsiung. / Novel terpenoids from Calocedrus macrolepis var. formosana. In: Chemistry and Biodiversity. 2011 ; Vol. 8, No. 10. pp. 1901-1907.
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