Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

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3 Citations (Scopus)

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.

Original languageEnglish
Pages (from-to)1901-1907
Number of pages7
JournalChemistry and Biodiversity
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • Calocedrus macrolepis var. formosana
  • Calocetriol
  • Cytotoxic activity
  • Diacetylcalocetriol
  • Diterpenoids
  • Ferrugimenthenol
  • Meroterpenoids
  • Secoabietanes

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Molecular Biology
  • Molecular Medicine

Cite this

Hsieh, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Li, Z-H., & Kuo, Y. H. (2011). Novel terpenoids from Calocedrus macrolepis var. formosana. Chemistry and Biodiversity, 8(10), 1901-1907. https://doi.org/10.1002/cbdv.201000237