Abstract

Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

Original languageEnglish
Pages (from-to)1263-1274
Number of pages12
JournalNanomedicine
Volume10
Issue number8
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Hyaluronic acid
Hydrogels
Hyaluronic Acid
tumor
Doxorubicin
Tumors
cancer
Lymphatic System
UCON 50-HB-5100
Hydrogel
Injections
acid
Poloxamer
Neoplasms
Magnesium Chloride
Colonic Neoplasms
targeting
Metal ions
Germany
Metals

Keywords

  • doxorubicin
  • hyaluronic acid
  • hydrogel
  • intratumoral
  • Pluronic F127

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Cite this

Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors. / Jhan, Hua Jing; Liu, Jun Jen; Chen, Ying Chen; Liu, Der Zen; Sheu, Ming Thau; Ho, Hsiu O.

In: Nanomedicine, Vol. 10, No. 8, 01.04.2015, p. 1263-1274.

Research output: Contribution to journalArticle

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AU - Jhan, Hua Jing

AU - Liu, Jun Jen

AU - Chen, Ying Chen

AU - Liu, Der Zen

AU - Sheu, Ming Thau

AU - Ho, Hsiu O.

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N2 - Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

AB - Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

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