Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines

Ting Wei Yu, Ho Yen Chueh, Ching Chou Tsai, Cheng Tao Lin, Jiantai Timothy Qiu

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Granulocyte macrophage-colony stimulating factor (GM-CSF) is a potent immunomodulatory cytokine that is known to facilitate vaccine efficacy by promoting the development and prolongation of both humoral and cellular immunity. In the past years we have generated a novel codon-optimized GM-CSF gene as an adjuvant. The codon-optimized GM-CSF gene significantly increased protein expression levels in all cells tested and helped in generating a strong immune responses against HIV-1 Gag and HPV-associated cancer. Here, we review the literature dealing with the adjuvant activity of GM-CSF both in animal models and clinical trials. We anticipate that the codon-optimized GM-CSF gene offers a practical molecular strategy for potentiating immune responses to tumor cell-based vaccinations as well as other immunotherapeutic strategies.

Original languageEnglish
Pages (from-to)3020-3028
Number of pages9
JournalHuman Vaccines and Immunotherapeutics
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

Keywords

  • cancer vaccine
  • cytotoxic T cells
  • GM-CSF
  • immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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