Novel epigallocatechin-3-gallate (Egcg)-loaded mesoporous bioglass scaffolds for bone recruitment applications

Shih Fu Ou, Yuan Li Tsao, Wei Chun Lin, Yi Ting Wang, Liping Wang, Fang Yu Fan

Research output: Contribution to journalArticlepeer-review

Abstract

Bioglass-based material has been widely used in the field of biomedical science. In this study, the proper concentration of epigallocatechin-3-gallate (EGCG) for a mesoporous bioglass (MBG) scaffold was determined based on the sponge replication method. The fabrication procedure performed using a foam exchange technique resulted in an interconnected network of pores scaffolds with no cracks. In the minimum bactericidal concentrations of the bacteria assessed, the antibacterial concentration of EGCG against E. coli (200 µg/mL) was higher than that against S. aureus (25 µg/mL). The MBG and EGCG-MBG scaffolds exhibited excellent apatite mineralization and drug release abilities (the highest cumulative drug release from the EGCG-MBG scaffold was 75.37%). Thus, a 200 µg/mL EGCG can prevent cell apoptosis and directly enhance cell proliferation. Hence, a low-dose EGCGMBG scaffold is another option for bone recruitment material.

Original languageEnglish
Article number243
Pages (from-to)1-9
Number of pages9
JournalApplied Sciences (Switzerland)
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • Antibacterial
  • Drug release
  • Epigallocatechin-3-gallate
  • Foam exchange technique
  • Mesoporous bioglass scaffold

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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