Novel dextran modified bacterial cellulose hydrogel accelerating cutaneous wound healing

Shin Ping Lin, Hsiu Ni Kung, You Shan Tsai, Tien Ni Tseng, Kai Di Hsu, Kuan Chen Cheng

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Development of an ideal wound dressing to efficiently improve the wound healing process is an important issue in wound care. The present study aims to develop a dextran/bacterial cellulose (BC) hydrogel and to evaluate its performance in wound healing applications. The assessments include material properties (morphology, thermostability and its mechanical properties), cytotoxicity, cell proliferation and wound healing. The results show that the addition of dextran affected the network structure of BC resulting in decreased decomposition temperature (339–261 °C), water content (98.7–89.2%), and tensile strength (23–0.61 MPa). However, the elongation rates were kept at approximately 33–28% in BC, 10% and 20% in dextran modified groups. Cell-based experiments showed that the dextran-modified BC hydrogel promoted enhanced cell proliferation without cytotoxicity compared to unmodified BC. Finally, the in vivo wound healing test demonstrated that dextran-modified BC hydrogel can accelerate the wound healing process and facilitate skin maturation, which suggests that dextran/BC hydrogel is a promising wound dressing for clinical applications.

Original languageEnglish
Pages (from-to)4927-4937
Number of pages11
JournalCellulose
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 1 2017
Externally publishedYes

Keywords

  • Bacterial cellulose
  • Dextran
  • Hydrogel
  • In vivo
  • Wound dressing
  • Wound healing

ASJC Scopus subject areas

  • Polymers and Plastics

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  • Cite this

    Lin, S. P., Kung, H. N., Tsai, Y. S., Tseng, T. N., Hsu, K. D., & Cheng, K. C. (2017). Novel dextran modified bacterial cellulose hydrogel accelerating cutaneous wound healing. Cellulose, 24(11), 4927-4937. https://doi.org/10.1007/s10570-017-1448-x