Abstract

Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalInternational Journal of General Medicine
Volume9
DOIs
Publication statusPublished - Jun 11 2016

Fingerprint

Malignant Pleural Effusion
Pleural Effusion
Biomarkers
Pleurisy
Interleukins
Innate Immunity
Interferons
Tuberculosis
Neoplasms
Proteins

Keywords

  • Biomarkers
  • Lung cancer
  • Malignant pleural effusion
  • Tuberculous pleural effusion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion",
abstract = "Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P",
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author = "Chen, {Kuan Yuan} and Feng, {Po Hao} and Chang, {Chih Cheng} and Chen, {Tzu Tao} and Chuang, {Hsiao Chi} and Lee, {Chun Nin} and Su, {Chien Ling} and Lin, {Lian Yu} and Lee, {Kang Yun}",
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T1 - Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion

AU - Chen, Kuan Yuan

AU - Feng, Po Hao

AU - Chang, Chih Cheng

AU - Chen, Tzu Tao

AU - Chuang, Hsiao Chi

AU - Lee, Chun Nin

AU - Su, Chien Ling

AU - Lin, Lian Yu

AU - Lee, Kang Yun

PY - 2016/6/11

Y1 - 2016/6/11

N2 - Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

AB - Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

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KW - Lung cancer

KW - Malignant pleural effusion

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