Nontyphoidal Salmonella bacteremia in previously healthy children: Analysis of 199 episodes

Ming Han Tsai, Yhu Chering Huang, Cheng Hsun Chiu, Meng Hsiu Yen, Luan Yin Chang, Pen Yi Lin, Tzou Yien Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

BACKGROUND: Nontyphoidal Salmonella (NTS) bacteremia is not rare in otherwise healthy children in Taiwan. Few studies described the clinical manifestations and outcomes of NTS bacteremia in previously healthy children. METHODS: Children with blood culture positive for NTS treated at Chang Gung Children's Hospital between May 1996 and June 2003 were identified from the microbiology logbook. Patients who had underlying events or concomitant diseases were excluded. RESULTS: We evaluated 199 patients. One hundred and eighteen (59.3%) were male children and 184 (92.5%) were between 3 months and 5 years of age. Fever (97.0%) and diarrhea (79.9%) were the most common initial presentations. Leukocytosis (leukocyte >15,000/mm) and elevated serum C-reactive protein concentration (≥10 mg/L) were present in 14.6% and 79.4% of the patients, respectively. Eighty-three percent of 184 patients with antibiotic treatment received a third- or fourth-generation cephalosporin as definitive antibiotic therapy. Focal suppurative infections were present in 5 children (2.5%) on initial evaluation, and included meningitis in 2 and osteomyelitis in 3. Neither metastatic complications nor clinically recurrent diseases were found during a follow-up period of at least 12 months after treatment. No fatalities occurred in this series. CONCLUSIONS: In healthy children, NTS bacteremia was relatively benign and extraintestinal focal suppurative infections were infrequently seen. Less than 10 days of appropriate antibiotic treatment is probably adequate for those without a suppurative focus of infection.

Original languageEnglish
Pages (from-to)909-913
Number of pages5
JournalPediatric Infectious Disease Journal
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

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Bacteremia
Salmonella
Focal Infection
Anti-Bacterial Agents
Leukocytosis
Osteomyelitis
Cephalosporins
Therapeutics
Microbiology
Taiwan
Meningitis
C-Reactive Protein
Blood Proteins
Diarrhea
Leukocytes
Fever
Infection

Keywords

  • Bacteremia
  • Children
  • Nontyphoidal Salmonella

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Nontyphoidal Salmonella bacteremia in previously healthy children : Analysis of 199 episodes. / Tsai, Ming Han; Huang, Yhu Chering; Chiu, Cheng Hsun; Yen, Meng Hsiu; Chang, Luan Yin; Lin, Pen Yi; Lin, Tzou Yien.

In: Pediatric Infectious Disease Journal, Vol. 26, No. 10, 10.2007, p. 909-913.

Research output: Contribution to journalArticle

Tsai, Ming Han ; Huang, Yhu Chering ; Chiu, Cheng Hsun ; Yen, Meng Hsiu ; Chang, Luan Yin ; Lin, Pen Yi ; Lin, Tzou Yien. / Nontyphoidal Salmonella bacteremia in previously healthy children : Analysis of 199 episodes. In: Pediatric Infectious Disease Journal. 2007 ; Vol. 26, No. 10. pp. 909-913.
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abstract = "BACKGROUND: Nontyphoidal Salmonella (NTS) bacteremia is not rare in otherwise healthy children in Taiwan. Few studies described the clinical manifestations and outcomes of NTS bacteremia in previously healthy children. METHODS: Children with blood culture positive for NTS treated at Chang Gung Children's Hospital between May 1996 and June 2003 were identified from the microbiology logbook. Patients who had underlying events or concomitant diseases were excluded. RESULTS: We evaluated 199 patients. One hundred and eighteen (59.3{\%}) were male children and 184 (92.5{\%}) were between 3 months and 5 years of age. Fever (97.0{\%}) and diarrhea (79.9{\%}) were the most common initial presentations. Leukocytosis (leukocyte >15,000/mm) and elevated serum C-reactive protein concentration (≥10 mg/L) were present in 14.6{\%} and 79.4{\%} of the patients, respectively. Eighty-three percent of 184 patients with antibiotic treatment received a third- or fourth-generation cephalosporin as definitive antibiotic therapy. Focal suppurative infections were present in 5 children (2.5{\%}) on initial evaluation, and included meningitis in 2 and osteomyelitis in 3. Neither metastatic complications nor clinically recurrent diseases were found during a follow-up period of at least 12 months after treatment. No fatalities occurred in this series. CONCLUSIONS: In healthy children, NTS bacteremia was relatively benign and extraintestinal focal suppurative infections were infrequently seen. Less than 10 days of appropriate antibiotic treatment is probably adequate for those without a suppurative focus of infection.",
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