Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients

Shuo Ming Ou, Yung Tai Chen, Pei Wen Chao, Yi Jung Lee, Chia Jen Liu, Chiu Mei Yeh, Tzeng Ji Chen, Tzen Wen Chen, Wu Chang Yang, Szu Yuan Li

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these patients. To identify any association between NSAID use and cancer risk in patients with end-stage renal disease on dialysis, we used Taiwan's National Health Insurance database to conduct a nationwide population-based, propensity score-matched cohort study. All cancers between groups were compared by Cox proportional hazards models. Compared to nonuse of NSAIDs, the use of non-COX-2-selective inhibitors (hazard ratio 0.81, 95% confidence interval 0.67-0.97) or COX-2-selective inhibitors (0.78, 0.62-0.98) was associated with a lower risk of developing cancer. NSAID use reduced the risk of respiratory (0.39, 0.19-0.79), breast (0.41, 0.19-0.89), kidney (0.58, 0.38-0.88), digestive tract (0.64, 0.49-0.85), and bladder cancers (0.73, 0.55-0.96). NSAID use, however, significantly increased risk for upper gastrointestinal bleeding (odds ratio, 1.15, 1.07-1.23) but not adverse cardiac or cerebrovascular events. Thus, NSAID use was associated with a lower risk of developing cancer in chronic dialysis patients; however, they should still be used with caution due to the side effects of gastrointestinal bleeding.

Original languageEnglish
Pages (from-to)198-205
Number of pages8
JournalKidney International
Volume84
Issue number1
DOIs
Publication statusPublished - Jul 2013

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients'. Together they form a unique fingerprint.

  • Cite this

    Ou, S. M., Chen, Y. T., Chao, P. W., Lee, Y. J., Liu, C. J., Yeh, C. M., Chen, T. J., Chen, T. W., Yang, W. C., & Li, S. Y. (2013). Nonsteroidal anti-inflammatory drug use is associated with cancer risk reduction in chronic dialysis patients. Kidney International, 84(1), 198-205. https://doi.org/10.1038/ki.2013.79