Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer

J. Whang‐Peng, T. Knutsen, A. Gazdar, S. M. Steinberg, H. Oie, I. Linnoila, J. Mulshine, M. Nau, J. D. Minna

Research output: Contribution to journalArticle

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Abstract

Cytogenetic studies were performed on 27 tumor cell lines (most of which were derived from metastatic lesions) and four fresh malignant pleural and pericardia! effusions from 30 patients with non‐small‐cell lung cancer (non‐SCLC). Many clonal structural (deletions and nonreciprocal translations) and numerical abnormalities were found in each specimen. Statistical analysis revealed these changes were nonrandomly distributed among the chromosomes. A statistically significant number of chromosomal breakpoints were seen in regions 1 q 1, 1 q3, 3p1, 3p2, 3q1, 3q2, 7q1, 13p1, 14p1, 15p1, and 17q1 when the regions were compared to the total haploid complement. In addition, when a given region was compared to other regions within the same chromosome, statistically significant numbers of breakpoints were noted for regions 1q3, 5q1, 7q1, 13p1, 14p1, 15p1, 16q2, 17q1, and 21p1. Specific chromosome bands showing the most frequent involvement in structural abnormalities were (in descending order) 3p 14.2, 3q21, 19q13, 11p15, 1q11, 7q111, 1q21, 3p23, and 3p21. The breakpoints indicate areas to look for new dominant oncogenes activated by translocations, while the areas of deletions and loss of material by nonreciprocal translocations highlight areas to search for recessive oncogenes. These cytogenetic studies represent strong evidence that multiple genetic lesions are associated with the development of metastatic lung cancer, and provide a roadmap to search for new genes involved in the pathogenesis of lung cancer.

Original languageEnglish
Pages (from-to)168-188
Number of pages21
JournalGenes, Chromosomes and Cancer
Volume3
Issue number3
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

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Lung Neoplasms
Chromosomes
Cytogenetics
Clonal Deletion
Haploidy
Pericardium
Tumor Cell Line
Tumor Suppressor Genes
Oncogenes
Genes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer. / Whang‐Peng, J.; Knutsen, T.; Gazdar, A.; Steinberg, S. M.; Oie, H.; Linnoila, I.; Mulshine, J.; Nau, M.; Minna, J. D.

In: Genes, Chromosomes and Cancer, Vol. 3, No. 3, 01.01.1991, p. 168-188.

Research output: Contribution to journalArticle

Whang‐Peng, J, Knutsen, T, Gazdar, A, Steinberg, SM, Oie, H, Linnoila, I, Mulshine, J, Nau, M & Minna, JD 1991, 'Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer', Genes, Chromosomes and Cancer, vol. 3, no. 3, pp. 168-188. https://doi.org/10.1002/gcc.2870030303
Whang‐Peng, J. ; Knutsen, T. ; Gazdar, A. ; Steinberg, S. M. ; Oie, H. ; Linnoila, I. ; Mulshine, J. ; Nau, M. ; Minna, J. D. / Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer. In: Genes, Chromosomes and Cancer. 1991 ; Vol. 3, No. 3. pp. 168-188.
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