Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats

Tzong Bor Sun, Terry B J Kuo, Cheryl C H Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Both hypotension and hypertension aggravate the damage of reperfusion injury after reconstructive microsurgery. The purpose of this study is to establish a theoretical guide for postoperative blood pressure control in optimizing the cutaneous perfusion and flap survival. Systemic arterial pressure was altered by the intravenous infusion of saline, sodium nitroprusside, phentolamine, and phenylephrine in thirty-two 280-350 g anesthetized Sprague Dawley rats. Power spectral analysis of systemic arterial pressure (SAP) and laser Doppler flowmetry (flux) of epigastric skin were used to reveal the blood pressure and cutaneous blood flow variabilities. Nonparallel responses of cutaneous perfusion and blood pressure were found. The baseline SAP and flux were 126.0 ± 1.4 mmHg and 57.2 ± 1.8 au, respectively. Sodium nitroprusside and phentolamine significantly decreased the SAP (71.1 ± 2.7 and 70.5 ± 1.5 mmHg, P < 0.0001). However, the corresponding responses in cutaneous perfusion were opposite (56.2 ± 3.1 au, P = 0.7389 and 36.2 ± 2.3 au, P < 0.0001). Phenylephrine significantly increased the SAP (171.7 ± 3.0 mmHg, P < 0.0001) but the flux of epigastric skin was decreased (44.4 ± 2.6 au, P < 0.0001). Phentolamine and phenylephrine showed negative effects on the systemic cardiac and vascular sympathetic modulations. Sodium nitroprusside had a trend in increasing systemic vasomotor activity. We suggested not using vasoconstrictors in treating intra and postoperative hypotension associated with free flap transfer. Nitric oxide donors are superior to α-adrenoceptor antagonists in preserving the cutaneous flap perfusion when treating postoperative hypertension.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalMicrosurgery
Volume29
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Arterial Pressure
Skin
Phentolamine
Nitroprusside
Phenylephrine
Perfusion
Blood Pressure
Hypotension
Hypertension
Laser-Doppler Flowmetry
Microsurgery
Nitric Oxide Donors
Free Tissue Flaps
Vasoconstrictor Agents
Reperfusion Injury
Intravenous Infusions
Adrenergic Receptors
Blood Vessels
Sprague Dawley Rats

ASJC Scopus subject areas

  • Surgery

Cite this

Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats. / Sun, Tzong Bor; Kuo, Terry B J; Yang, Cheryl C H.

In: Microsurgery, Vol. 29, No. 4, 2009, p. 319-325.

Research output: Contribution to journalArticle

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